Combining existing drug therapy is essential in develo** new therapeutic agents in
disease prevention and treatment. In preclinical investigations, combined effect of certain …

All forms of life produce nanosized extracellular vesicles called exosomes, which are
enclosed in lipid bilayer membranes. Exosomes engage in cell-to-cell communication and …

Drug delivery technologies have been proven to improve treatment outcomes in many ways,
including enhancing therapeutic efficacy, reducing toxicity, increasing patient compliance …

Osteoarthritis (OA) is a degenerative disease characterized by loss of articular cartilage and
chronic inflammation, involving multiple cellular dysfunctions and tissue lesions. The non …

Drug delivery is a key component of nanomedicine, and conventional delivery relies on the
adsorption or encapsulation of drug molecules to a nanomaterial. Many delivery vehicles …

Osteoarthritis (OA) is a widespread clinical disease characterized by cartilage degeneration
in middle-aged and elderly people. Currently, there is no effective treatment for OA apart …

Highlights•We categorize the challenges and corresponding solutions for nano-drug
delivery in OA.•We summarize the design and advantages of recent nano-drug delivery …

The occurrence of osteoarthritis (OA) is highly associated with the inflammatory hypoxic
microenvironment. Yet currently no attention has been paid to fabricating hypoxia …

Osteoarthritis is a chronic inflammatory disease characterized by cartilage degeneration.
Anti‐inflammatory therapy has limited effects, and effective reduction of cartilage wear …

One of the practical ways to manage the disease flares of arthritis is using an intra-articular
depot formulation of glucocorticoids. Hydrogels, as controllable drug delivery systems, are …