This review is concerned with the role of fibrillization of the amyloid β (Aβ)-peptide in
Alzheimer's disease (AD). The perspective is that of a physical chemist, and one aim is to …

Spider silk is strong and extensible but still biodegradable and well tolerated when
implanted, making it the ultimate biomaterial. Shortcomings that arise in replicating spider …

Peptides or proteins convert under some conditions from their soluble forms into highly
ordered fibrillar aggregates. Such transitions can give rise to pathological conditions ranging …

Amyloid β-protein (Aβ) assembly into toxic oligomeric and fibrillar structures is a seminal
event in Alzheimer's disease, therefore blocking this process could have significant …

The purpose of this work was to construct a consensus prediction algorithm of 'aggregation-
prone'peptides in globular proteins, combining existing tools. This allows comparison of the …

The fibrillization of peptides is relevant to many diseases based on the deposition of
amyloids. The formation of fibrils is being intensively studied, especially in terms of …

Increasing evidence indicates that many peptides and proteins can be converted in vitro into
highly organised amyloid structures, provided that the appropriate experimental conditions …

We have systematically studied the effects of 40 single point mutations on the conversion of
the denatured form of the α/β protein acylphosphatase (AcP) into insoluble aggregates. All …

Amyloid aggregation is a hallmark of several degenerative diseases affecting the brain or
peripheral tissues, whose intermediates (oligomers, protofibrils) and final mature fibrils …

The establishment of rules that link sequence and amyloid feature is critical for our
understanding of misfolding diseases. To this end, we have performed a saturation …