Recent technological advancements have enabled the profiling of a large number of
genome-wide features in individual cells. However, single-cell data present unique …

The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase
receptors. EGFR signaling cascade is a key regulator in cell proliferation, differentiation …

Proteins and their functional interactions form the backbone of the cellular machinery. Their
connectivity network needs to be considered for the full understanding of biological …

Abstract The Reactome Knowledgebase (https://reactome. org) provides molecular details of
signal transduction, transport, DNA replication, metabolism and other cellular processes as …

Abstract The Human Metabolome Database or HMDB (www. hmdb. ca) is a web-enabled
metabolomic database containing comprehensive information about human metabolites …

Abstract The Reactome Knowledgebase (https://reactome. org) provides molecular details of
signal transduction, transport, DNA replication, metabolism, and other cellular processes as …

Motivation Gene lists are routinely produced from various omic studies. Enrichment analysis
can link these gene lists with underlying molecular pathways and functional categories such …

Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …

INTRODUCTION A complete view of human biology can only be achieved by studying the
molecular components of its smallest functional unit, the cell. Cells are internally organized …

Pathway enrichment analysis helps researchers gain mechanistic insight into gene lists
generated from genome-scale (omics) experiments. This method identifies biological …