HT receptors expressed throughout the human body are targets for established therapeutics
and various drugs in development. Their diversity of structure and function reflects the …

Cannabidiol (CBD) is one of the cannabinoids with non-psychotropic action, extracted from
Cannabis sativa. CBD is a terpenophenol and it has received a great scientific interest …

Background & Aims The human gut microbiota can regulate production of serotonin (5-
hydroxytryptamine [5-HT]) from enterochromaffin cells. However, the mechanisms …

Dravet syndrome is a catastrophic childhood epilepsy with early-onset seizures, delayed
language and motor development, sleep disturbances, anxiety-like behaviour, severe …

Acquired brain injury (ABI), such as traumatic brain injury and stroke, is a leading cause of
disability worldwide, resulting in debilitating acute and chronic symptoms, as well as an …

Abstract Behavioral and Psychological Symptoms of Dementia (BPSD), present in almost
90% of patients with Alzheimer's Disease (AD), cause extensive impairment leading to …

Developmental and epileptic encephalopathies are rare, treatment-resistant epilepsies with
high seizure burden and non-seizure comorbidities. The antiseizure medication (ASM) …

Onset of many forms of epilepsy occurs after an initial epileptogenic insult or as a result of an
identified genetic defect. Given that the precipitating insult is known, these epilepsies are, in …

There is high variability in the response to antiepileptic treatment across people with
epilepsy. Genetic factors significantly contribute to such variability. Recent advances in the …

Epilepsy comorbidities and anti-epileptic drugs (AEDs) are currently the main limitations of
epilepsy treatment. Semaglutide is a glucagon like peptide-1 analogue that has entered the …