Heart failure with preserved ejection fraction (HFpEF) affects half of all patients with heart
failure worldwide, is increasing in prevalence, confers substantial morbidity and mortality …

Heart failure with preserved ejection fraction (HFpEF) accounts for nearly half of all heart
failure cases and has a prevalence that is expected to rise with the growing ageing …

In accordance with the comorbidity-inflammation paradigm, comorbidities and especially
metabolic comorbidities are presumed to drive development and severity of heart failure with …

Heart failure (HF) is the most rapidly growing cardiovascular health burden worldwide. HF
can be classified into three groups based on the percentage of the ejection fraction (EF) …

Cardiovascular diseases remain the leading cause of death worldwide, with pathological
fibrotic remodeling mediated by activated cardiac myofibroblasts representing a unifying …

Objectives This study prospectively evaluated endomyocardial biopsies in patients with
heart failure with preserved ejection fraction (HFpEF) to identify histopathologic phenotypes …

Aging is associated with an increased risk of cardiovascular disease and death. Here we
show that oral supplementation of the natural polyamine spermidine extends the lifespan of …

Background: Heart failure (HF) with preserved ejection fraction (HFpEF) constitutes half of all
HF but lacks effective therapy. Understanding of its myocardial biology remains limited …

This review aims to provide a translational perspective on recent developments in heart
failure with preserved ejection fraction (HFpEF), linking mechanistic insights to potential …

Background—Characterization of myocardial structural changes in heart failure with
preserved ejection fraction (HFpEF) has been hindered by the limited availability of human …