2011 update of the drug resistance mutations in HIV-1
VA Johnson, V Calvez, HF Günthard… - Topics in antiviral …, 2016 - pmc.ncbi.nlm.nih.gov
The development of more recently approved drugs that cannot be tested as monotherapy
precludes assessment of the impact of resistance on antiretroviral activity that is not …
precludes assessment of the impact of resistance on antiretroviral activity that is not …
HIV drug resistance against strand transfer integrase inhibitors
Integrase strand transfer inhibitors (INSTIs) are the newest class of antiretroviral drugs to be
approved for treatment and act by inhibiting the essential HIV protein integrase from …
approved for treatment and act by inhibiting the essential HIV protein integrase from …
Antiviral activity of bictegravir (GS-9883), a novel potent HIV-1 integrase strand transfer inhibitor with an improved resistance profile
M Tsiang, GS Jones, J Goldsmith… - Antimicrobial agents …, 2016 - Am Soc Microbiol
ABSTRACT Bictegravir (BIC; GS-9883), a novel, potent, once-daily, unboosted inhibitor of
HIV-1 integrase (IN), specifically targets IN strand transfer activity (50% inhibitory …
HIV-1 integrase (IN), specifically targets IN strand transfer activity (50% inhibitory …
Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication
Lens epithelium–derived growth factor (LEDGF/p75) is a cellular cofactor of HIV-1 integrase
that promotes viral integration by tethering the preintegration complex to the chromatin. By …
that promotes viral integration by tethering the preintegration complex to the chromatin. By …
[HTML][HTML] 2019 update of the drug resistance mutations in HIV-1
AM Wensing, V Calvez… - Topics in antiviral …, 2019 - ncbi.nlm.nih.gov
The 2019 edition of the IAS-USA drug resistance mutations list updates the Figure last
published in January 2017. The mutations listed are those that have been identified by …
published in January 2017. The mutations listed are those that have been identified by …
[HTML][HTML] HIV-1 drug resistance mutations: an updated framework for the second decade of HAART
RW Shafer, JM Schapiro - AIDS reviews, 2008 - ncbi.nlm.nih.gov
More than 200 mutations are associated with antiretroviral resistance to drugs belonging to
six licensed antiretroviral classes. More than 50 reverse transcriptase mutations are …
six licensed antiretroviral classes. More than 50 reverse transcriptase mutations are …
2014 Update of the drug resistance mutations in HIV-1
Methods The IAS–USA Drug Resistance Mutations Group is an independent, volunteer
panel of experts charged with delivering accurate, unbiased, and evidence-based …
panel of experts charged with delivering accurate, unbiased, and evidence-based …
Molecular basis of human immunodeficiency virus type 1 drug resistance: overview and recent developments
L Menéndez-Arias - Antiviral research, 2013 - Elsevier
The introduction of potent combination therapies in the mid-90s had a tremendous effect on
AIDS mortality. However, drug resistance has been a major factor contributing to …
AIDS mortality. However, drug resistance has been a major factor contributing to …
Integrase and integration: biochemical activities of HIV-1 integrase
Integration of retroviral DNA is an obligatory step of retrovirus replication because proviral
DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses …
DNA is the template for productive infection. Integrase, a retroviral enzyme, catalyses …
Development of antiretroviral drug resistance
MA Wainberg, GJ Zaharatos… - New England Journal of …, 2011 - Mass Medical Soc
Analysis of HIV drug resistance has identified sites on HIV target genes that convey
resistance to particular classes of agents. These data may be especially important in …
resistance to particular classes of agents. These data may be especially important in …