The extracellular matrix (ECM) is one of the major components of tumors that plays multiple
crucial roles, including mechanical support, modulation of the microenvironment, and a …

Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …

Cancer stemness is recognized as a key component of tumor development. Previously
coined" cancer stem cells"(CSCs) and believed to be a rare population with rigid …

Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Chimeric antigen receptor (CAR) T cells, T cells that have been genetically engineered to
express a receptor that recognizes a specific antigen, have given rise to breakthroughs in …

Patient-derived organoids (PDOs) recapitulate tumor architecture, contain cancer stem cells
and have predictive value supporting personalized medicine. Here we describe a large …

In the last decades, the role of the microenvironment in tumor progression and therapeutic
outcome has gained increasing attention. Cancer-associated fibroblasts (CAFs) have …

CD44, a non-kinase transmembrane glycoprotein, is overexpressed in several cell types
including cancer stem cells and frequently shows alternative spliced variants that are …

Wnt signaling is one of the key cascades regulating development and stemness, and has
also been tightly associated with cancer. The role of Wnt signaling in carcinogenesis has …

Colorectal cancer stem cells (CSCs) express Lgr5 and display extensive stem cell-like
multipotency and self-renewal and are thought to seed metastatic disease. Here, we used a …