Transition-metal-catalyzed, coordination-assisted C (sp3)–H functionalization has
revolutionized synthetic planning over the past few decades as the use of these directing …

Transition-metal-catalyzed C–H activation has developed a contemporary approach to the
omnipresent area of retrosynthetic disconnection. Scientific researchers have been tempted …

Over the past decade, the landscape of molecular synthesis has gained major impetus by
the introduction of late-stage functionalization (LSF) methodologies. C–H functionalization …

During the past decades, synthetic organic chemistry discovered that directing group
assisted C–H activation is a key tool for the expedient and siteselective construction of C–C …

Transition metal catalysis has contributed immensely to C–C bond formation reactions over
the last few decades, and alkylation is no exception. The superiority of such methodologies …

The transition metal-catalyzed enantioselective C–H functionalization strategy has
revolutionized the logic of natural product synthesis. However, previous applications have …

The late‐stage modification of structurally complex peptides bears great potential for drug
discovery, crop protection, and the pharmaceutical industry, among others. Whereas …

Differentiating between two highly similar C–H bonds in a given molecule remains a
fundamental challenge in synthetic organic chemistry. Directing group assisted strategies for …

The construction of carbon–carbon bonds is a central tenet of modern synthetic chemistry.
Metal-catalyzed C–H functionalization can serve as a particularly powerful tool for achieving …

Bioorthogonal late‐stage diversification of structurally complex peptides bears enormous
potential for drug discovery and molecular imaging, among other applications. Herein, we …