ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Apolipoprotein E (apoE) is a lipid carrier in both the peripheral and the central nervous
systems. Lipid-loaded apoE lipoprotein particles bind to several cell surface receptors to …

Among the three human apolipoprotein E (apoE) isoforms, apoE4 increases the risk of
Alzheimer's disease (AD). While transporting cholesterol is a primary function, apoE also …

We employed homologous recombination in embryonic stem cells to produce mice lacking
functional LDL receptor genes. Homozygous male and female mice lacking LDL receptors …

Although it has been known for over 50 years that lipoprotein lipase (LPL) hydrolyzes
triglyceride in chylomicrons, during the past half decade there has been a reinterest in the …

Apolipoprotein E (APOE) genetic variants have been shown to modify Alzheimer's disease
(AD) risk. We previously identified an APOE3 variant (APOE 3-V236E), named APOE3 …

Publisher Summary This chapter focuses on the role of apoE in lipoprotein metabolism and
the most completely described function of the protein. Apolipoprotein E (apoE) is one of the …

The plasma clearance of intestinally derived remnant lipoproteins by the liver is a process
that likely involves three steps. Our model suggests that the initial rapid clearance by the …

Type III hyperlipoproteinemia (HLP) is a genetic disorder characterized by accumulation of
remnant lipoproteins in the plasma and development of premature atherosclerosis. Although …

Chylomicrons are formed in the intestine and transport dietary triglyceride to peripheral
tissues and cholesterol to the liver. The enzyme lipoprotein lipase, with apolipoprotein (apo) …