Gastrointestinal dysfunction in autism spectrum disorder: the role of the mitochondria and the enteric microbiome

RE Frye, S Rose, J Slattery… - Microbial ecology in …, 2015 - Taylor & Francis
Autism spectrum disorder (ASD) affects a significant number of individuals worldwide with
the prevalence continuing to grow. It is becoming clear that a large subgroup of individuals …

[HTML][HTML] Management of sleep disorders among children and adolescents with neurodevelopmental disorders: A practical guide for clinicians

MO Ogundele, C Yemula - World journal of clinical pediatrics, 2022 - ncbi.nlm.nih.gov
There is a complex relationship between sleep disorders and childhood
neurodevelopmental, emotional, behavioral and intellectual disorders (NDEBID). NDEBID …

The Lancet Commission on the future of care and clinical research in autism

C Lord, T Charman, A Havdahl, P Carbone… - The Lancet, 2022 - thelancet.com
Executive summary Affecting about 78 million people worldwide, autism is a condition of
global importance because of its prevalence and the degree to which it can affect individuals …

Autism genes are selectively targeted by environmental pollutants including pesticides, heavy metals, bisphenol A, phthalates and many others in food, cosmetics or …

CJ Carter, RA Blizard - Neurochemistry international, 2016 - Elsevier
The increasing incidence of autism suggests a major environmental influence. Epidemiology
has implicated many candidates and genetics many susceptibility genes. Gene/environment …

Melatonin as a Mediator of the Gut Microbiota–Host Interaction: Implications for Health and Disease

MÁ Bonmatí-Carrión, MA Rol - Antioxidants, 2023 - mdpi.com
In recent years, the role played by melatonin on the gut microbiota has gained increasingly
greater attention. Additionally, the gut microbiota has been proposed as an alternative …

[HTML][HTML] Melatonin in sleep disorders

JJ Poza, M Pujol, JJ Ortega-Albás, O Romero - Neurología (English Edition …, 2022 - Elsevier
Melatonin is the main hormone involved in the control of the sleep-wake cycle. It is easily
synthesisable and can be administered orally, which has led to interest in its use as a …

Abnormalities in the genes that encode Large Amino Acid Transporters increase the risk of Autism Spectrum Disorder

L Cascio, CF Chen, R Pauly, S Srikanth… - Molecular genetics & …, 2020 - Wiley Online Library
Background Autism spectrum disorder (ASD) is a common neurodevelopmental disorder
whose molecular mechanisms are largely unknown. Several studies have shown an …

Identification and treatment of pathophysiological comorbidities of autism spectrum disorder to achieve optimal outcomes

RE Frye, DA Rossignol - Clinical Medicine Insights …, 2016 - journals.sagepub.com
Despite the fact that the prevalence of autism spectrum disorder (ASD) continues to rise, no
effective medical treatments have become standard of care. In this paper we review some of …

Novel biomarkers of metabolic dysfunction is autism spectrum disorder: potential for biological diagnostic markers

AM Khemakhem, RE Frye, A El-Ansary… - Metabolic brain …, 2017 - Springer
Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is behaviorally
defined by social and communication impairments and restricted interests and repetitive …

[HTML][HTML] Efficacy and safety of supplemental melatonin for delayed sleep–wake phase disorder in children: an overview

D Mantle, M Smits, M Boss, I Miedema, I van Geijlswijk - Sleep Medicine: X, 2020 - Elsevier
Delayed sleep–wake phase disorder (DSPD) is the most frequently occurring intrinsic
circadian rhythm sleep–wake disorder, with the highest prevalence in adolescence …