Pathophysiological mechanisms of atrial fibrillation: a translational appraisal

U Schotten, S Verheule, P Kirchhof… - Physiological …, 2011 - journals.physiology.org
Atrial fibrillation (AF) is an arrhythmia that can occur as the result of numerous different
pathophysiological processes in the atria. Some aspects of the morphological and …

A hybrid maze procedure for long-standing persistent atrial fibrillation

JL Cox, A Churyla, SC Malaisrie, DT Pham… - The Annals of Thoracic …, 2019 - Elsevier
Background Catheter ablation (CA) for long-standing persistent atrial fibrillation (LSPAF) is
suboptimal, and open surgical ablation, although more successful, is too invasive to be a …

The cox-maze procedure for lone atrial fibrillation: a single-center experience over 2 decades

T Weimar, S Schena, MS Bailey… - Circulation …, 2012 - Am Heart Assoc
Background—The Cox-Maze procedure (CMP) has achieved high success rates in the
therapy of atrial fibrillation (AF) while becoming progressively less invasive. This report …

Conditional immortalization of human atrial myocytes for the generation of in vitro models of atrial fibrillation

N Harlaar, SO Dekker, J Zhang, RR Snabel… - Nature Biomedical …, 2022 - nature.com
The lack of a scalable and robust source of well-differentiated human atrial myocytes
constrains the development of in vitro models of atrial fibrillation (AF). Here we show that …

Identification of repetitive activation patterns using novel computational analysis of multielectrode recordings during atrial fibrillation and flutter in humans

EG Daoud, Z Zeidan, JD Hummel, R Weiss… - JACC: Clinical …, 2017 - jacc.org
Objectives: The purpose of this study was to assess computational analysis of 64-electrode
basket catheter (BC) recordings of atrial fibrillation (AF) and atrial flutter using novel …

Unmasking arrhythmogenic hubs of reentry driving persistent atrial fibrillation for patient‐specific treatment

BJ Hansen, J Zhao, KM Helfrich, N Li… - Journal of the …, 2020 - Am Heart Assoc
Background Atrial fibrillation (AF) driver mechanisms are obscured to clinical multielectrode
map** approaches that provide partial, surface‐only visualization of unstable 3 …

The temporal variability of dominant frequency and complex fractionated atrial electrograms constrains the validity of sequential map** in human atrial fibrillation

N Habel, P Znojkiewicz, N Thompson, JG Müller… - Heart Rhythm, 2010 - Elsevier
BACKGROUND: It has been proposed that sequential map** of dominant frequency (DF)
and complex fractionated atrial electrograms (CFAE) can identify target sites for ablation of …

Distinctive patterns of dominant frequency trajectory behavior in drug‐refractory persistent atrial fibrillation: preliminary characterization of spatiotemporal instability

JL Salinet, JH Tuan, AJ Sandilands… - Journal of …, 2014 - Wiley Online Library
Frequency Trajectory of Atrial Fibrillation Introduction The role of substrates in the
maintenance of persistent atrial fibrillation (persAF) remains poorly understood. The use of …

Maintenance of atrial fibrillation: are reentrant drivers with spatial stability the key?

BJ Hansen, TA Csepe, J Zhao, AJ Ignozzi… - Circulation …, 2016 - Am Heart Assoc
Here, we discuss how the visualization of microanatomic reentrant AF drivers becomes
much more complex when intramural conduction and the 3D atrial structure are considered …

Mechanisms of atrial fibrillation: rotors, ionic determinants, and excitation frequency

O Berenfeld, J Jalife - Cardiology clinics, 2014 - cardiology.theclinics.com
Atrial fibrillation (AF) is associated with increased morbidity and mortality in patients with
cardiovascular disease and its prevalence in the general population continues to increase. 1 …