We present a comprehensive analysis of all ring systems (both heterocyclic and
nonheterocyclic) in clinical trial compounds and FDA-approved drugs. We show 67% of …

Due to the continued emergence of resistance and a lack of new and promising antibiotics,
bacterial infection has become a major public threat. High-throughput screening (HTS) …

The exploration of privileged structures in drug discovery is a rapidly emerging theme in
medicinal chemistry. These structures represent a class of molecules capable of binding to …

Natural products and their derivatives have historically been invaluable as a source of
therapeutic agents. However, in the past decade, research into natural products in the …

This paper emphasizes the importance of rigorous validation as a crucial, integral
component of Quantitative Structure Property Relationship (QSPR) model development. We …

The identification of small-molecule modulators of protein function, and the process of
transforming these into high-content lead series, are key activities in modern drug discovery …

One of the most important characteristics of Quantitative Structure ActivityRelashionships
(QSAR) models is their predictive power. The latter can bedefined as the ability of a model to …

Abstract Cisplatin [cis-DDP, cis-diamminedichloroplatinum (II)] is a potent anticancer drug
that has been used successfully to treat tumors of the head, neck, lungs, and genitourinary …

Herein we report a novel strategy for the design and construction of natural and natural
product-like libraries based on the principle of privileged structures, a term originally …

The fast identification of quality lead compounds in the pharmaceutical industry through a
combination of high throughput synthesis and screening has become more challenging in …