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Roles of natural killer cells in immunity to cancer, and applications to immunotherapy
Great strides have been made in recent years towards understanding the roles of natural
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …
killer (NK) cells in immunity to tumours and viruses. NK cells are cytotoxic innate lymphoid …
Development of NK cell-based cancer immunotherapies through receptor engineering
A Page, N Chuvin, J Valladeau-Guilemond… - Cellular & Molecular …, 2024 - nature.com
Natural killer (NK) cell-based immunotherapies are attracting increasing interest in the field
of cancer treatment. Early clinical trials have shown promising outcomes, alongside …
of cancer treatment. Early clinical trials have shown promising outcomes, alongside …
Challenges and new technologies in adoptive cell therapy
P Zhang, G Zhang, X Wan - Journal of Hematology & Oncology, 2023 - Springer
Adoptive cell therapies (ACTs) have existed for decades. From the initial infusion of tumor-
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …
infiltrating lymphocytes to the subsequent specific enhanced T cell receptor (TCR)-T and …
Advances in acute myeloid leukemia
LF Newell, RJ Cook - Bmj, 2021 - bmj.com
Acute myeloid leukemia (AML) is an uncommon but potentially catastrophic diagnosis with
historically high mortality rates. The standard of care treatment remained unchanged for …
historically high mortality rates. The standard of care treatment remained unchanged for …
Natural killer cell homing and trafficking in tissues and tumors: from biology to application
GH Ran, YQ Lin, L Tian, T Zhang, DM Yan… - … and Targeted Therapy, 2022 - nature.com
Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …
against cancer. Although some evidence shows that NK cells can develop in secondary …
Pain-resolving immune mechanisms in neuropathic pain
Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …
Exploring the NK cell platform for cancer immunotherapy
JA Myers, JS Miller - Nature reviews Clinical oncology, 2021 - nature.com
Natural killer (NK) cells are cytotoxic lymphocytes of the innate immune system that are
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …
capable of killing virally infected and/or cancerous cells. Nearly 20 years ago, NK cell …
NK cell-based cancer immunotherapy: from basic biology to clinical development
S Liu, V Galat, Y Galat4, YKA Lee… - Journal of hematology & …, 2021 - Springer
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in
immune activation against abnormal cells. Different from events required for T cell activation …
immune activation against abnormal cells. Different from events required for T cell activation …
CAR-NK cells: A promising cellular immunotherapy for cancer
Natural Killer (NK) cells and CD8+ cytotoxic T cells are two types of immune cells that can
kill target cells through similar cytotoxic mechanisms. With the remarkable success of …
kill target cells through similar cytotoxic mechanisms. With the remarkable success of …
NK cells and solid tumors: therapeutic potential and persisting obstacles
Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic
activity, have recently attracted attention as potential anticancer therapeutics. While NK cells …
activity, have recently attracted attention as potential anticancer therapeutics. While NK cells …