Various chemical modifications of all RNA transcripts, or epitranscriptomics, have emerged
as crucial regulators of RNA metabolism, attracting significant interest from both basic and …

Genetic mechanisms have been at the forefront of our exploration into the substrate of
adaptive evolution and phenotypic diversification. However, genetic variation only accounts …

Abstract N6-methyladenosine (m6A) RNA modification impacts mRNA fate primarily via
reader proteins, which dictate processes in development, stress, and disease. Yet little is …

IDH1mut gliomas produce high levels of D-2-hydroxyglutarate (D-2-HG), an oncometabolite
capable of inhibiting α-ketoglutarate–dependent dioxygenases critical to a range of cellular …

Early diagnosis of cancer is crucial for treatment and recovery. Carcinoembryonic antigen
(CEA), as an important tumor marker, its traditional detection methods rely on costly …

Transgenic expression of a double-stranded RNA in plants can induce silencing of
homologous mRNAs in fungal pathogens. Although such host-induced gene silencing is …

Abstract N6-methyladenosine (m6A), the most abundant mRNA modification, is deposited in
mammals/insects/plants by m6A methyltransferase complexes (MTC) comprising a catalytic …

Abstract N 6-methyladenosine (m 6 A) is the most prevalent internal mRNA modification.
Recent research has highlighted its role as a key regulator of gene expression, influencing …

RNA N 6-methyladenosine (m6A) modification is important for regulating gene expression
and innate immune responses to viral infection. HIV-1 in vitro infection induces a significant …

Despite effective antiretroviral therapy reducing HIV-1 viral loads to undetectable levels, the
presence of latently infected CD4+ T cells poses a major barrier to HIV-1 cure. N 6 …