High-throughput sequencing-based methods and their applications in the study of
transcriptomes have revolutionized our understanding of alternative splicing. Networks of …

Precise pre-mRNA splicing, essential for appropriate protein translation, depends on the
presence of consensus “cis” sequences that define exon-intron boundaries and regulatory …

The splicing of pre-mRNAs into mature transcripts is remarkable for its precision, but the
mechanisms by which the cellular machinery achieves such specificity are incompletely …

Background & Aims In recent years, circular RNAs (circRNAs) have been shown to have
critical regulatory roles in cancer biology. However, the contributions of circRNAs to …

Circular RNAs (circRNAs) derived from back-spliced exons have been widely identified as
being co-expressed with their linear counterparts. A single gene locus can produce multiple …

Exon circularization has been identified from many loci in mammals, but the detailed
mechanism of its biogenesis has remained elusive. By using genome-wide approaches and …

Next-generation sequencing has revolutionized clinical diagnostic testing. Yet, for a
substantial proportion of patients, sequence information restricted to exons and exon–intron …

Precursor messenger RNA (pre-mRNA) splicing is a critical step in the posttranscriptional
regulation of gene expression, providing significant expansion of the functional proteome of …

Sequence-specific RNA-binding proteins (RBPs) bind to pre-mRNA to control alternative
splicing, but it is not yet possible to read the'splicing code'that dictates splicing regulation on …

We describe the identification and characterization of circular intronic long noncoding RNAs
in human cells, which accumulate owing to a failure in debranching. The formation of such …