Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Dysregulation of the Notch signaling pathway, which is highly conserved across species,
can drive aberrant epigenetic modification, transcription, and translation. Defective gene …

Two decades ago successful transfection of antigen presenting cells (APC) in vivo was
demonstrated which resulted in the induction of primary adaptive immune responses. Due to …

Abstract The US Food and Drug Administration (FDA) recently approved pembrolizumab, an
anti-programmed cell death protein 1 cancer immunotherapeutic, for use in advanced solid …

Nanoparticles (NPs) are not only employed in many biomedical applications in an
engineered form, but also occur in our environment, in a more hazardous form. NPs interact …

In the 21st century, an array of microbiological and molecular allow antigens for new
vaccines to be specifically identified, designed, produced and delivered with the aim of …

Methods A non-systematic review was done through a search on the following databases:
MEDLINE, EMBASE, Global Health, The Cochrane Library (Cochrane Database of …

Protein therapeutics have drastically changed the landscape of treatment for many diseases
by providing a regimen that is highly specific and lacks many off-target toxicities. The clinical …

In subunit vaccines, aluminum salts (Alum) are commonly used as adjuvants, but with limited
cellular immune responses. To overcome this limitation, CpG oligodeoxynucleotides (ODNs) …

Stroke represents one of the neurological diseases most responsible for death and
permanent disability in the world. Different factors, such as thrombus, emboli and …