Citrullination in the pathology of inflammatory and autoimmune disorders: recent advances and future perspectives
Numerous post-translational modifications (PTMs) govern the collective metabolism of a cell
through altering the structure and functions of proteins. The action of the most prevalent …
through altering the structure and functions of proteins. The action of the most prevalent …
Protein arginine deiminases (PADs): biochemistry and chemical biology of protein citrullination
Conspectus Proteins are well-known to undergo a variety of post-translational modifications
(PTMs). One such PTM is citrullination, an arginine modification that is catalyzed by a group …
(PTMs). One such PTM is citrullination, an arginine modification that is catalyzed by a group …
Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation
HD Lewis, J Liddle, JE Coote, SJ Atkinson… - Nature chemical …, 2015 - nature.com
PAD4 has been strongly implicated in the pathogenesis of autoimmune, cardiovascular and
oncological diseases through clinical genetics and gene disruption in mice. New selective …
oncological diseases through clinical genetics and gene disruption in mice. New selective …
[HTML][HTML] Chemical biology of protein arginine modifications in epigenetic regulation
Post-translational modifications (PTMs) of histone proteins are a hallmark of epigenetic
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
regulation. They provide a mechanism to modulate chromatin structure and constitute the …
Activity-based protein profiling: Recent advances in medicinal chemistry
H Deng, Q Lei, Y Wu, Y He, W Li - European journal of medicinal chemistry, 2020 - Elsevier
Activity-based protein profiling (ABPP) has become an emerging chemical proteomic
approach to illustrate the interaction mechanisms between compounds and proteins. This …
approach to illustrate the interaction mechanisms between compounds and proteins. This …
PAD4 and its inhibitors in cancer progression and prognosis
D Zhu, Y Lu, Y Wang, Y Wang - Pharmaceutics, 2022 - mdpi.com
The systemic spread of malignancies and the risk of cancer-associated thrombosis are
major clinical challenges in cancer therapy worldwide. As an important post-translational …
major clinical challenges in cancer therapy worldwide. As an important post-translational …
Chemical biology of protein citrullination by the protein A arginine deiminases
Citrullination is a post-translational modification (PTM) that converts peptidyl-arginine into
peptidyl-citrulline; citrullination is catalyzed by the protein arginine deiminases (PADs). This …
peptidyl-citrulline; citrullination is catalyzed by the protein arginine deiminases (PADs). This …
Development of a selective inhibitor of protein arginine deiminase 2
A Muth, V Subramanian, E Beaumont… - Journal of medicinal …, 2017 - ACS Publications
Protein arginine deiminase 2 (PAD2) plays a key role in the onset and progression of
multiple sclerosis, rheumatoid arthritis, and breast cancer. To date, no PAD2-selective …
multiple sclerosis, rheumatoid arthritis, and breast cancer. To date, no PAD2-selective …
Chemical proteomic platform to identify citrullinated proteins
Anti-citrullinated protein antibodies (ACPAs) are a hallmark of rheumatoid arthritis (RA) and
are routinely used for disease diagnosis. Protein citrullination is also increased in cancer …
are routinely used for disease diagnosis. Protein citrullination is also increased in cancer …
An interplay of structure and intrinsic disorder in the functionality of peptidylarginine deiminases, a family of key autoimmunity-related enzymes
Citrullination is a post-translation modification of proteins, where the proteinaceous arginine
residues are converted to non-coded citrulline residues. The immune tolerance to such …
residues are converted to non-coded citrulline residues. The immune tolerance to such …