Synthetic approaches and pharmaceutical applications of chloro-containing molecules for drug discovery: A critical review
At present more than 250 FDA approved chlorine containing drugs were available in the
market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is …
market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is …
An insight of alpha-amylase inhibitors as a valuable tool in the management of type 2 diabetes mellitus
R Bashary, M Vyas, SK Nayak, A Suttee… - Current diabetes …, 2020 - ingentaconnect.com
Background: Among the millions of people around the world, the most prevalent metabolic
disorder is diabetes mellitus. Due to the drawbacks which are associated with commercially …
disorder is diabetes mellitus. Due to the drawbacks which are associated with commercially …
Biscoumarin-1, 2, 3-triazole hybrids as novel anti-diabetic agents: Design, synthesis, in vitro α-glucosidase inhibition, kinetic, and docking studies
A novel series of biscoumarin-1, 2, 3-triazole hybrids 6a-n was prepared and evaluated for α-
glucosidase inhibitory potential. All fourteen derivatives exhibited excellent α-glucosidase …
glucosidase inhibitory potential. All fourteen derivatives exhibited excellent α-glucosidase …
Synthesis, characterization, molecular docking, and biological activities of coumarin–1, 2, 3‐triazole‐acetamide hybrid derivatives
Coumarins and their derivatives are receiving increasing attention due to numerous
biochemical and pharmacological applications. In this study, a series of novel coumarin–1 …
biochemical and pharmacological applications. In this study, a series of novel coumarin–1 …
Synthesis and biological evaluation of new benzimidazole-1, 2, 3-triazole hybrids as potential α-glucosidase inhibitors
N Asemanipoor, M Mohammadi-Khanaposhtani… - Bioorganic …, 2020 - Elsevier
In this study, a series of benzimidazole-1, 2, 3-triazole hybrids 8a-n as new α-glucosidase
inhibitors were designed and synthesized. In vitro α-glucosidase inhibition activity results …
inhibitors were designed and synthesized. In vitro α-glucosidase inhibition activity results …
Synthesis of new indazole based dual inhibitors of α-glucosidase and α-amylase enzymes, their in vitro, in silico and kinetics studies
The current study describes the discovery of novel inhibitors of α-glucosidase and α-
amylase enzymes. For that purpose, new hybrid analogs of N-hydrazinecarbothioamide …
amylase enzymes. For that purpose, new hybrid analogs of N-hydrazinecarbothioamide …
Indole-nitroimidazole conjugates as efficient manipulators to decrease the genes expression of methicillin-resistant Staphylococcus aureus
ZZ Li, VKR Tangadanchu, N Battini… - European Journal of …, 2019 - Elsevier
The biological resistance of methicillin-resistant staphylococcus aureus (MRSA) has pushed
synthetic antibiotics to the forefront. To combat the resistance of MRSA, our new effort …
synthetic antibiotics to the forefront. To combat the resistance of MRSA, our new effort …
[HTML][HTML] New benzoxazole-based sulphonamide hybrids analogs as potent inhibitors of α-amylase and α-glucosidase: Synthesis and in vitro evaluation along with in …
The development of drugs resistance in diabetes mellitus is a growing clinical problem,
creates many challenges for patient. To overcome these problems, there is a serious …
creates many challenges for patient. To overcome these problems, there is a serious …
Synthesis of indole-based-thiadiazole derivatives as a potent inhibitor of α-glucosidase enzyme along with in silico study
Abstract A series of nineteen (1–19) indole-based-thiadiazole derivatives were synthesized,
characterized by 1 HNMR, 13 C NMR, MS, and screened for α-glucosidase inhibition. All …
characterized by 1 HNMR, 13 C NMR, MS, and screened for α-glucosidase inhibition. All …
Synthesis of indole derivatives as diabetics II inhibitors and enzymatic kinetics study of α-glucosidase and α-amylase along with their in-silico study
In this study, we have investigated a series of indole-based compounds for their inhibitory
study against pancreatic α-amylase and intestinal α-glucosidase activity. Inhibitors of …
study against pancreatic α-amylase and intestinal α-glucosidase activity. Inhibitors of …