At present more than 250 FDA approved chlorine containing drugs were available in the
market and many pharmaceutically important drug candidates in pre-clinical trials. Thus, it is …

Background: Among the millions of people around the world, the most prevalent metabolic
disorder is diabetes mellitus. Due to the drawbacks which are associated with commercially …

The emergence of antibiotic resistance highlights the critical need for novel antimicrobial
agents. In this study, we investigated the synthesis of methyl α-D-glucopyranoside (1) …

A novel series of biscoumarin-1, 2, 3-triazole hybrids 6a-n was prepared and evaluated for α-
glucosidase inhibitory potential. All fourteen derivatives exhibited excellent α-glucosidase …

Coumarins and their derivatives are receiving increasing attention due to numerous
biochemical and pharmacological applications. In this study, a series of novel coumarin–1 …

The development of drugs resistance in diabetes mellitus is a growing clinical problem,
creates many challenges for patient. To overcome these problems, there is a serious …

In this study, a series of benzimidazole-1, 2, 3-triazole hybrids 8a-n as new α-glucosidase
inhibitors were designed and synthesized. In vitro α-glucosidase inhibition activity results …

Abstract Indole based thiadiazole derivatives (1–18) were synthesized and evaluated for
their acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibition. The IC 50 …

The current study describes the discovery of novel inhibitors of α-glucosidase and α-
amylase enzymes. For that purpose, new hybrid analogs of N-hydrazinecarbothioamide …

The biological resistance of methicillin-resistant staphylococcus aureus (MRSA) has pushed
synthetic antibiotics to the forefront. To combat the resistance of MRSA, our new effort …