Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …

The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

Mitochondrial metabolism must constantly adapt to stress conditions in order to maintain
bioenergetic levels related to cellular functions. This absence of proper adaptation can be …

Radiation therapy is one of the major tools of cancer treatment, and is widely used for a
variety of malignant tumours. Radiotherapy causes DNA damage directly by ionization or …

In recent years, lipid metabolism has garnered significant attention as it provides the
necessary building blocks required to sustain tumor growth and serves as an alternative fuel …

Resistance to therapeutic agents, either intrinsic or acquired, is currently a major problem in
the treatment of cancers and occurs in virtually every type of anti-cancer therapy. Therefore …

Resistance to ionizing radiation, a first-line therapy for many cancers, is a major clinical
challenge. Personalized prediction of tumor radiosensitivity is not currently implemented …

Resistance of cancer cells to chemotherapy is the first cause of cancer-associated death.
Thus, new strategies to deal with the evasion of drug response and to improve clinical …

In situ tumor vaccination is preliminarily pursued to strengthen antitumor immune response.
Immunogenic tumor cell death spontaneously releases abundant antigens and adjuvants for …

Simple Summary Cancer cells directly control nutrient uptake and utilization in a different
manner from that of normal cells. These metabolic changes drive growth, proliferation of …