RNA-binding proteins (RBPs) play a critical role in the regulation of various RNA processes,
including splicing, cleavage and polyadenylation, transport, translation and degradation of …

Understanding the pathogenic mechanisms of disease mutations is critical to advancing
treatments. ALS-associated mutations in the gene encoding the microtubule motor KIF5A …

RNA-binding proteins control the metabolism of RNAs at all stages of their lifetime. They are
critically required for the post-transcriptional regulation of gene expression in a wide variety …

Activation of p53-dependent apoptosis is critical for tumor suppression but aberrant
activation of p53 also leads to developmental defects and heart failure. Here, we found that …

Background: Mutations in genes encoding sarcomeric proteins lead to failures in sarcomere
assembly, the building blocks of contracting muscles, resulting in cardiomyopathies that are …

Lens transparency is established by abundant accumulation of crystallin proteins and loss of
organelles in the fiber cells. It requires an efficient translation of lens messenger RNAs …

Abnormal interaction between non-coding RNAs has been demonstrated to be a common
molecular event in various human cancers, but its significance and underlying mechanisms …

SARS-CoV-2 is a betacoronavirus with single-stranded positive-sense RNA, which is a
serious global threat to human health. Understanding the molecular mechanism of viral …

Mutations in the key transcription factor, SOX2, alone account for 20% of anophthalmia (no
eye) and microphthalmia (small eye) birth defects in humans—yet its regulation is not well …

The p53 family is made up of three transcription factors: p53, p63, and p73. These proteins
are well-known regulators of cell function and play a crucial role in controlling various …