The immune system plays a critical role in sha** all facets of cancer, from the early
initiation stage through to metastatic disease and resistance to therapy. Our understanding …

Nucleotide binding oligomerization domain (NOD)-like receptors are cytoplasmic pattern-
recognition receptors that together with RIG-I-like receptor (retinoic acid-inducible gene 1) …

The nucleotide-binding oligomerization domain (NOD) protein, NOD2, belonging to the
intracellular NOD-like receptor family, detects conserved motifs in bacterial peptidoglycan …

Cytosolic NOD-like receptors (NLRs) have been associated with human diseases including
infections, cancer, and autoimmune and inflammatory disorders. These innate immune …

Innate immunity comprises several inflammation-related modulatory pathways which receive
signals from an array of membrane-bound and cytoplasmic pattern recognition receptors …

Background Recently, many studies have reported that some botanicals and natural
products were able to regulate NOD-like receptor signaling. NOD-like receptors (NLRs) …

NOD1 {nucleotide-binding oligomerization domain 1; NLRC [NOD-LRR (leucine-rich repeat)
family with CARD (caspase recruitment domain) 1]} and NOD2 (NLRC2) are among the …

Nucleotide binding oligomerization domain 2 (NOD2) is a recognized innate immune sensor
which can initiate potent immune response against pathogens. Many innate immune …

The tumor microenvironment (TME) is a complex environment where cancer cells reside and
interact with different types of cells, secreted factors, and the extracellular matrix …

Autophagy is an evolutionarily conserved catabolic process by which cellular components
are sequestered into a double-membrane vesicle and delivered to the lysosome for terminal …