Filopodia are thin, actin-rich plasma-membrane protrusions that function as antennae for
cells to probe their environment. Consequently, filopodia have an important role in cell …

Dendritic spines are small actin-rich protrusions from neuronal dendrites that form the
postsynaptic part of most excitatory synapses and are major sites of information processing …

The growth and migration of neurons require continuous remodelling of the neuronal
cytoskeleton, providing a versatile cellular framework for force generation and guided …

Heterozygous loss-of-function mutations in SHANK2 are associated with autism spectrum
disorder (ASD). We generated cortical neurons from induced pluripotent stem cells derived …

Fused in sarcoma (FUS) and TAR DNA-binding protein 43 (TDP-43) are RNA-binding
proteins pathogenetically linked to amyotrophic lateral sclerosis (ALS) and frontotemporal …

Actin is a versatile and ubiquitous cytoskeletal protein that plays a major role in both the
establishment and the maintenance of neuronal polarity. For a long time, the most prominent …

During brain development, proper neuronal migration and morphogenesis is critical for the
establishment of functional neural circuits. Here we report that srGAP2 negatively regulates …

GPR56, an orphan G protein-coupled receptor (GPCR) from the family of adhesion GPCRs,
plays an indispensable role in cortical development and lamination. Mutations in the GPR56 …

Assembly of actin filament networks drives many fundamental cellular processes, including
cell polarization and migration, endocytosis, intracellular trafficking, and maintenance of …

Ena/VASP proteins are conserved regulators of actin dynamics that have important roles in
several physiological processes such as morphogenesis, axon guidance, endothelial barrier …