Acute-on-chronic liver failure: pathophysiological mechanisms and management

A Khanam, S Kottilil - Frontiers in medicine, 2021 - frontiersin.org
Acute-on-chronic liver failure (ACLF) is a multifaceted condition with poor treatment options
and high short-term mortality. ACLF can develop in patients with or without liver cirrhosis …

Insights into the role of granulocyte colony-stimulating factor in severe alcoholic hepatitis

CK Kedarisetty, A Kumar, SK Sarin - Seminars in liver disease, 2021 - thieme-connect.com
Alcohol use disorder is the predominant cause of chronic liver disease globally. The
standard of care for the treatment of alcoholic hepatitis, corticosteroids, has been shown to …

Expression of Notch–Hif-1α signaling pathway in liver regeneration of rats

Y Li, Y Xu, R Wang, W Li, W He… - Journal of International …, 2020 - journals.sagepub.com
Objective To investigate whether the Notch–Hif-1α signaling pathway is involved in liver
regeneration. Methods Rats were divided into two groups and treated with daily …

In vitro efficacy of liver microenvironment in bone marrow mesenchymal stem cell differentiation

M Eissa, N Elarabany, A Hyder - In Vitro Cellular & Developmental Biology …, 2020 - Springer
Bone marrow–derived mesenchymal stem cells (BM-MSCs) represent an interesting
alternative to liver or hepatocyte transplantation to treat liver injuries. Many studies have …

Still'dwelling in the possibility'-critical update on stem cell therapy for acute on chronic liver failure

CA Philips, P Augustine - World Journal of Stem Cells, 2020 - pmc.ncbi.nlm.nih.gov
Stem cells therapy could improve survival in patients with liver failure. Studies on stem cell
therapy and related growth factors in decompensated cirrhosis has been on the forefront but …

The role of growth factors on hepatic damage in rats with obstructive jaundice

O Turk, B Badak, E Ates, E Dundar, E Sutken - Springerplus, 2016 - Springer
In this study, we investigated the affect and the role of growth factors on liver damage. 110
Sprague–Dawley rats were divided into 11 groups: a sham group, a control group, HGF …

[PDF][PDF] Differentiation of bone mesenchymal stem cells into hepatocyte-like cells induced by liver tissue homogenate

XK **ng, HG Feng, ZQ Yuan - Genetics and Molecular Research, 2016 - funpecrp.com.br
This study investigated the efficacy and feasibility of inducing the differentiation of bone
marrow-derived mesenchymal stem cells (BMSCs) into hepatocyte-like cells in vitro using …

[PDF][PDF] Erythropoietin in Predicting Prognosis in Patients with Acute-on-Chronic Liver Failure.

T Alempijevic, S Zec, V Nikolic, A Veljkovic… - … of Gastrointestinal & …, 2016 - researchgate.net
ABSTRACT Background & Aims: Acute-on-chronic liver failure (ACLF) is characterized by a
rapid progression to multiple organ failure and is associated with a very high mortality rate of …

Growth factor therapy for decompensated cirrhosis: Much ado about nothing?

CA Philips, P Augustine, S Mathew, GC Valiathan… - Hepatology, 2018 - journals.lww.com
We read with interest, the study by Verma et al.(1), on the utility of granulocyte colony-
stimulating factor (GCSF) and growth hormone (GH)(Group A) or GCSF alone (Group B) …

[PDF][PDF] Liver transplantation for hepatitis B-related acute-on-chronic liver failure patients

QL Guo, BW Duan, SC Lu, N Li - Int J Clin Exp Med, 2017 - e-century.us
Aims: This study aimed to investigate the impact of perioperative cytokines, clinical variables
and scoring systems on the short-term outcomes of liver transplantation (LT) in hepatitis B …