Aortic aneurysm is a chronic disease characterized by localized expansion of the aorta,
including the ascending aorta, arch, descending aorta, and abdominal aorta. Although aortic …

Background Aortic aneurysms (AA) are pathological dilations of the aorta, associated with
an overall mortality rate up to 90% in case of rupture. In addition to dilation, the aortic layers …

Abstract Aim The “2022 ACC/AHA Guideline for the Diagnosis and Management of Aortic
Disease” provides recommendations to guide clinicians in the diagnosis, genetic evaluation …

2010 ACCF/AHA/AATS/ACR/ASA/SCA/SCAI/SIR/STS/SVM Guidelines for the Diagnosis and
Management of Patients With Thoracic Aortic Disease | Circulation Science Volunteer Warning …

Objective The phenotypic plasticity of vascular smooth muscle cells (VSMCs) is central to
vessel growth and remodeling, but also contributes to cardiovascular pathologies. New …

Thoracic aortic aneurysm is a potentially life-threatening condition in that it places patients at
risk for aortic dissection or rupture. However, our modern understanding of the pathogenesis …

The importance of maintaining contractile function in aortic smooth muscle cells (SMCs) is
evident by the fact that heterozygous mutations in the major structural proteins or kinases …

Aortic aneurysm is common, accounting for 1–2% of all deaths in industrialized countries.
Early theories of the causes of human aneurysm mostly focused on inherited or acquired …

The mature heart valves are made up of highly organized extracellular matrix (ECM) and
valve interstitial cells (VICs) surrounded by an endothelial cell layer. The ECM of the valves …

The major function of vascular smooth muscle cells (SMCs) is contraction to regulate blood
pressure and flow. SMC contractile force requires cyclic interactions between SMC α-actin …