[HTML][HTML] Understanding retroviral life cycle and its genomic RNA packaging
Members of the family Retroviridae are important animal and human pathogens. Being
obligate parasites, their replication involves a series of steps during which the virus hijacks …
obligate parasites, their replication involves a series of steps during which the virus hijacks …
Human retrovirus genomic RNA packaging
Two non-covalently linked copies of the retrovirus genome are specifically recruited to the
site of virus particle assembly and packaged into released particles. Retroviral RNA …
site of virus particle assembly and packaged into released particles. Retroviral RNA …
Human T-cell leukemia virus type 1 uses a specific tRNAPro isodecoder to prime reverse transcription
Human T-cell leukemia virus type 1 (HTLV-1) is the only oncogenic human retrovirus
discovered to date. All retroviruses are believed to use a host cell tRNA to prime reverse …
discovered to date. All retroviruses are believed to use a host cell tRNA to prime reverse …
A purine loop and the primer binding site are critical for the selective encapsidation of mouse mammary tumor virus genomic RNA by Pr77Gag
A Chameettachal, V Vivet-Boudou… - Nucleic acids …, 2021 - academic.oup.com
Retroviral RNA genome (gRNA) harbors cis-acting sequences that facilitate its specific
packaging from a pool of other viral and cellular RNAs by binding with high-affinity to the …
packaging from a pool of other viral and cellular RNAs by binding with high-affinity to the …
Molecular Biology and Diversification of Human Retroviruses
Studies of retroviruses have led to many extraordinary discoveries that have advanced our
understanding of not only human diseases, but also molecular biology as a whole. The most …
understanding of not only human diseases, but also molecular biology as a whole. The most …
Identification of a putative Gag binding site critical for feline immunodeficiency virus genomic RNA packaging
The retroviral Gag precursor plays a central role in the selection and packaging of viral
genomic RNA (gRNA) by binding to virus-specific packaging signal (s)(psi or ψ). Previously …
genomic RNA (gRNA) by binding to virus-specific packaging signal (s)(psi or ψ). Previously …
[HTML][HTML] The Assembly of HTLV-1—How Does It Differ from HIV-1?
Retroviral assembly is a highly coordinated step in the replication cycle. The process is
initiated when the newly synthesized Gag and Gag-Pol polyproteins are directed to the inner …
initiated when the newly synthesized Gag and Gag-Pol polyproteins are directed to the inner …
Rous sarcoma virus genomic RNA dimerization capability in vitro is not a prerequisite for viral infectivity
S Liu, R Kaddis Maldonado, T Rye-McCurdy, C Binkley… - Viruses, 2020 - mdpi.com
Retroviruses package their full-length, dimeric genomic RNA (gRNA) via specific
interactions between the Gag polyprotein and a “Ψ” packaging signal located in the gRNA …
interactions between the Gag polyprotein and a “Ψ” packaging signal located in the gRNA …
Portrait of the intrinsically disordered side of the HTLV-1 proteome
DL Lyngdoh, H Shukla, A Sonkar, R Anupam… - ACS …, 2019 - ACS Publications
Intrinsically disordered proteins (IDPs) lack an ordered 3D structure. These proteins contain
one or more intrinsically disordered protein regions (IDPRs). IDPRs interact promiscuously …
one or more intrinsically disordered protein regions (IDPRs). IDPRs interact promiscuously …
HIV-1 integrase binding to genomic RNA 5′-UTR induces local structural changes in vitro and in virio
Abstract Background During HIV-1 maturation, Gag and Gag-Pol polyproteins are
proteolytically cleaved and the capsid protein polymerizes to form the honeycomb capsid …
proteolytically cleaved and the capsid protein polymerizes to form the honeycomb capsid …