Melatonin and its metabolites vs oxidative stress: From individual actions to collective protection

A Galano, RJ Reiter - Journal of Pineal Research, 2018 - Wiley Online Library
Oxidative stress (OS) represents a threat to the chemical integrity of biomolecules including
lipids, proteins, and DNA. The associated molecular damage frequently results in serious …

Computational strategies for predicting free radical scavengers' protection against oxidative stress: where are we and what might follow?

A Galano, J Raúl Alvarez‐Idaboy - International Journal of …, 2019 - Wiley Online Library
Oxidative stress, which is frequently induced by an overproduction of free radicals (FR),
poses a high risk to human health. Thus, finding efficient strategies for scavenging FR is a …

Methylene blue in photodynamic therapy: From basic mechanisms to clinical applications

JP Tardivo, A Del Giglio, CS De Oliveira… - Photodiagnosis and …, 2005 - Elsevier
Methylene blue (MB) is a molecule that has been playing important roles in microbiology
and pharmacology for some time. It has been widely used to stain living organisms, to treat …

How biology handles nitrite

LB Maia, JJG Moura - Chemical Reviews, 2014 - ACS Publications
Nitrite is one of the players in the broad nitrogen biogeochemical cycle. This nitrogen oxo-
anion is involved in key pathways crucial to life on Earth and to the planetary “recycling” of …

Photodynamic therapy: porphyrins and phthalocyanines as photosensitizers

LM Moreira, FV dos Santos, JP Lyon… - Australian journal of …, 2008 - CSIRO Publishing
The present work is focussed on the principles of photodynamic therapy (PDT), emphasizing
the photochemical mechanisms of reactive oxygen species formation and the consequent …

Mechanisms of nitrite bioactivation

DB Kim-Shapiro, MT Gladwin - Nitric Oxide, 2014 - Elsevier
It is now accepted that the anion nitrite, once considered an inert oxidation product of nitric
oxide (NO), contributes to hypoxic vasodilation, physiological blood pressure control, and …

Nitrite reductase activity of cytochrome c

S Basu, NA Azarova, MD Font, SB King, N Hogg… - Journal of Biological …, 2008 - jbc.org
Small increases in physiological nitrite concentrations have now been shown to mediate a
number of biological responses, including hypoxic vasodilation, cytoprotection after …

A transcriptional response to singlet oxygen, a toxic byproduct of photosynthesis

JR Anthony, KL Warczak, TJ Donohue - Proceedings of the National …, 2005 - pnas.org
The ability of phototrophs to convert light into biological energy is critical for life on Earth.
However, there can be deleterious consequences associated with this bioenergetic …

Singlet oxygen stimulates mitochondrial bioenergetics in brain cells

SG Sokolovski, EU Rafailov, AY Abramov… - Free Radical Biology …, 2021 - Elsevier
Oxygen, in form of reactive oxygen species (ROS), has been shown to participate in
oxidative stress, one of the major triggers for pathology, but also is a main contributor to …