Diseases of muscle that are caused by pathological interactions between muscle and the
immune system are devastating, but rare. However, muscle injuries that involve trauma and …

Adult skeletal muscle in mammals is a stable tissue under normal circumstances but has
remarkable ability to repair after injury. Skeletal muscle regeneration is a highly orchestrated …

Macrophages are tissue-resident or infiltrated immune cells critical for innate immunity,
normal tissue development, homeostasis, and repair of damaged tissue. Macrophage …

The repair process of damaged tissue involves the coordinated activities of several cell
types in response to local and systemic signals. Following acute tissue injury, infiltrating …

Recent discoveries reveal complex interactions between skeletal muscle and the immune
system that regulate muscle regeneration. In this review, we evaluate evidence that …

Macrophages control the resolution of inflammation through the transition from a
proinflammatory (M1) to an anti-inflammatory (M2) phenotype. Here, we present evidence …

We examined the function of IL-10 in regulating changes in macrophage phenotype during
muscle growth and regeneration following injury. Our findings showed that the Th1 cytokine …

Muscle regeneration is a closely regulated process that involves a variety of cell types such
as satellite cells, myofibers, fibroadipogenic progenitors, endothelial cells, and inflammatory …

Macrophages (MPs) exert either beneficial or deleterious effects on tissue repair, depending
on their activation/polarization state. They are crucial for adult skeletal muscle repair, notably …

Strenuous exercise is a potent stimulus to induce beneficial skeletal muscle adaptations,
ranging from increased endurance due to mitochondrial biogenesis and angiogenesis, to …