Phenotypic drug discovery (PDD), which involves harnessing biological systems directly to
uncover effective drugs, has undergone a resurgence in recent years. The rapid …

The liver is an organ with critical importance for drug treatment as the disposition and
response to a given drug is often determined by its hepatic metabolism. Patient-specific …

The liver is the largest solid organ in the body and is critical for metabolic and immune
functions. However, little is known about the cells that make up the human liver and its …

Physiologically, four major types of hepatic cells–the liver sinusoidal endothelial cells,
Kupffer cells, hepatic stellate cells, and hepatocytes–reside inside liver sinusoids and …

Organ-on-chip (OOC) systems recapitulate key biological processes and responses in vitro
exhibited by cells, tissues, and organs in vivo. Accordingly, these models of both health and …

Drug-induced hepatotoxicity is a leading cause of drug withdrawal from the market. High-
throughput screening utilizing in vitro liver models is critical for early-stage liver toxicity …

Bioreactors hold a lot of promise for tissue engineering and regenerative medicine
applications. They have multiple uses including cell cultivation for therapeutic production …

Regulation of cosmetic testing and poor predictivity of preclinical drug studies has spurred
efforts to develop new methods for systemic toxicity. Current in vitro assays do not fully …

This article describes our next generation human Liver Acinus MicroPhysiology System
(LAMPS). The key demonstration of this study was that Zone 1 and Zone 3 …

Hepatocytes are differentiated cells that account for 80% of the hepatic volume and perform
all major functions of the liver. In vivo, after an acute insult, adult hepatocytes retain their …