Phosphoinositides are signalling lipids derived from phosphatidylinositol, a ubiquitous
phospholipid in the cytoplasmic leaflet of eukaryotic membranes. Initially discovered for their …

Cells of the innate immune system, notably macrophages, neutrophils and dendritic cells,
perform essential antimicrobial and homeostatic functions. These functions rely on the …

Membrane protrusions at the leading edge of cells, known as lamellipodia, drive cell
migration in many normal and pathological situations. Lamellipodial protrusion is powered …

Endocytosis is required for internalization of micronutrients and turnover of membrane
components. Endophilin has been assigned as a component of clathrin-mediated …

Cell-directed changes in the ligand-binding affinity ('activation') of integrins regulate cell
adhesion and migration, extracellular matrix assembly and mechanotransduction, thereby …

Axon outgrowth and guidance to the proper target requires the coordination of filamentous
(F)-actin and microtubules (MTs), the dynamic cytoskeletal polymers that promote shape …

The dynamic remolding of the actin cytoskeleton is a critical part of most cellular activities,
and malfunction of cytoskeletal proteins results in various human diseases. The transition …

Regulation of cell-cell and cell-matrix interaction is essential for the normal physiology of
metazoans and is important in many diseases. Integrin adhesion receptors can rapidly …

The PI3K signaling pathway regulates cell growth and movement and is heavily mutated in
cancer. Class I PI3Ks synthesize the lipid messenger PI (3, 4, 5) P 3. PI (3, 4, 5) P 3 can be …

Integrin-dependent cell adhesions come in different shapes and serve in different cell types
for tasks ranging from cell-adhesion, migration, and the remodeling of the extracellular …