[HTML][HTML] Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease
Inflammation occurs as a result of exposure of tissues and organs to harmful stimuli such as
microbial pathogens, irritants, or toxic cellular components. The primary physical …
microbial pathogens, irritants, or toxic cellular components. The primary physical …
[HTML][HTML] The emerging role of Nrf2 in mitochondrial function
AT Dinkova-Kostova, AY Abramov - Free Radical Biology and Medicine, 2015 - Elsevier
The transcription factor NF-E2 p45-related factor 2 (Nrf2; gene name NFE2L2) allows
adaptation and survival under conditions of stress by regulating the gene expression of …
adaptation and survival under conditions of stress by regulating the gene expression of …
Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates …
LE Tebay, H Robertson, ST Durant, SR Vitale… - Free Radical Biology …, 2015 - Elsevier
Abstract Nuclear factor-erythroid 2 p45-related factor 2 (Nrf2) regulates the basal and stress-
inducible expression of a battery of genes encoding key components of the glutathione …
inducible expression of a battery of genes encoding key components of the glutathione …
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
Inflammation and oxidative stress are thought to promote tissue damage in multiple
sclerosis. Thus, novel therapeutics enhancing cellular resistance to free radicals could prove …
sclerosis. Thus, novel therapeutics enhancing cellular resistance to free radicals could prove …
The cytoprotective role of the Keap1–Nrf2 pathway
An elaborate network of highly inducible proteins protects aerobic cells against the
cumulative damaging effects of reactive oxygen intermediates and toxic electrophiles, which …
cumulative damaging effects of reactive oxygen intermediates and toxic electrophiles, which …
Nrf2–ARE pathway: an emerging target against oxidative stress and neuroinflammation in neurodegenerative diseases
Neurodegenerative diseases (NDDs) are predicted to be the biggest health concern in this
century and the second leading cause of death by 2050. The main risk factor of these …
century and the second leading cause of death by 2050. The main risk factor of these …
Neuroinflammation in Parkinson's disease: its role in neuronal death and implications for therapeutic intervention
Parkinson's disease (PD) is the second most common neurodegenerative disease, after
Alzheimer's disease. The potential causes of PD remain uncertain, but recent studies …
Alzheimer's disease. The potential causes of PD remain uncertain, but recent studies …
A perspective on Nrf2 signaling pathway for neuroinflammation: a potential therapeutic target in Alzheimer's and Parkinson's diseases
Neuroinflammation plays a pivotal role in Alzheimer's disease (AD) and Parkinson's disease
(PD), the leading causes of dementia. These neurological disorders are characterized by the …
(PD), the leading causes of dementia. These neurological disorders are characterized by the …
Stress-activated cap'n'collar transcription factors in aging and human disease
Cap'n'collar (Cnc) transcription factors are conserved in metazoans and have important
developmental and homeostatic functions. The vertebrate Nrf1, Nrf2, and Nrf3; the …
developmental and homeostatic functions. The vertebrate Nrf1, Nrf2, and Nrf3; the …
NRF2 as a therapeutic target in neurodegenerative diseases
MS Brandes, NE Gray - ASN neuro, 2020 - journals.sagepub.com
Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …
the pathogenesis of numerous neurodegenerative conditions including among others …