Protein and phosphoinositide kinases have been successfully exploited as drug targets in
various disease areas, principally in oncology. In malaria, several protein kinases are under …

CRISPR/Cas9 approaches are revolutionizing our ability to perform functional genomics
across a wide range of organisms, including the Plasmodium parasites that cause malaria …

Cyclic GMP (cGMP)-dependent protein kinase (protein kinase G [PKG]) is essential for
microneme secretion, motility, invasion, and egress in apicomplexan parasites, However …

Abstract Calcium Dependent Protein Kinases are key effectors of calcium signaling in
malaria parasite. PfCDPK1 is critical for asexual development of Plasmodium falciparum, but …

ABSTRACT Introduction The deployment of Artemisinin-based combination therapies and
transmission control measures led to a decrease in the global malaria burden over the …

The human malaria parasite Plasmodium falciparum requires efficient egress out of an
infected red blood cell for pathogenesis. This egress event is highly coordinated and is …

Efforts to knock out Plasmodium falciparum calcium-dependent protein kinase 1 (Pf CDPK1)
from asexual erythrocytic stage have not been successful, indicating an indispensable role …

In malaria parasites, evolution of parasitism has been linked to functional optimisation.
Despite this optimisation, most members of a calcium-dependent protein kinase (CDPK) …

The cyclic nucleotides 3′, 5′-cyclic adenosine monophosphate (cAMP) and 3′, 5′-
cyclic guanosine monophosphate (cGMP) are intracellular messengers found in most …

Advances in the genetics, function, and stage-specificity of Plasmodium kinases has driven
robust efforts to identify targets for the design of antimalarial therapies. Reverse genomics …