Immune regulation is fundamental to any immune response to ensure that it is appropriate
for the perceived threat to the host. Following cell and organ transplantation, it is essential to …

In the past 40 years, liver transplantation has evolved from a high-risk procedure to one that
offers high success rates for reversal of liver dysfunction and excellent patient and graft …

Establishing long-term allograft acceptance without the requirement for continuous
immunosuppression, a condition known as allograft tolerance, is a highly desirable …

The prevalence of IBD is rising in the Western world. Despite an increasing repertoire of
therapeutic targets, a significant proportion of patients suffer chronic morbidity. Studies in …

Organ transplantation appears today to be the best alternative to replace the loss of vital
organs induced by various diseases. Transplants can, however, also be rejected by the …

Immunosuppressive drugs can be completely withdrawn in up to 20% of liver transplant
recipients, commonly referred to as 'operationally'tolerant. Immune characterization of these …

Strategies to prevent organ transplant rejection whilst minimizing long-term
immunosuppression are currently under intense investigation with regulatory T cells (Tregs) …

Transplantation of organs between genetically different individuals of the same species
causes a T cell–mediated immune response that, if left unchecked, results in rejection and …

A fraction of liver transplant recipients are able to discontinue all immunosuppressive
therapies without rejecting their grafts and are said to be operationally tolerant to the …

Background. Although immunosuppression withdrawal in kidney recipients usually leads to
rejection, in some patients it does not, leading to a state of clinical operational tolerance …