Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses

K Peng, Y Zheng, W **a, ZW Mao - Chemical Society Reviews, 2023 - pubs.rsc.org
The great clinical success of cisplatin and its derivatives has convinced people that metal
complexes could play a more significant role in human cancer therapy. However, targeting …

Metallodrugs are unique: opportunities and challenges of discovery and development

EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …

Bioorthogonal catalytic patch

Z Chen, H Li, Y Bian, Z Wang, G Chen, X Zhang… - Nature …, 2021 - nature.com
Bioorthogonal catalysis mediated by transition metals has inspired a new subfield of artificial
chemistry complementary to enzymatic reactions, enabling the selective labelling of …

Targeted photoredox catalysis in cancer cells

H Huang, S Banerjee, K Qiu, P Zhang, O Blacque… - Nature …, 2019 - nature.com
Hypoxic tumours are a major problem for cancer photodynamic therapy. Here, we show that
photoredox catalysis can provide an oxygen-independent mechanism of action to combat …

Packaging and delivering enzymes by amorphous metal-organic frameworks

X Wu, H Yue, Y Zhang, X Gao, X Li, L Wang… - Nature …, 2019 - nature.com
Enzymatic catalysis in living cells enables the in-situ detection of cellular metabolites in
single cells, which could contribute to early diagnosis of diseases. In this study, enzyme is …

An ultrasound-activatable platinum prodrug for sono-sensitized chemotherapy

G Liu, Y Zhang, H Yao, Z Deng, S Chen, Y Wang… - Science …, 2023 - science.org
Despite the great success achieved by photoactivated chemotherapy, eradicating deep
tumors using external sources with high tissue penetration depth remains a challenge. Here …

Metal complexes for therapeutic applications

J Karges, RW Stokes, SM Cohen - Trends in chemistry, 2021 - cell.com
Metal complexes have been widely used for applications in the chemical and physical
sciences due to their unique electronic and stereochemical properties. For decades the use …

Adsorption of Molecules on Defective CeO2 for Advanced Catalysis

S Zhang, Z Tian, Y Ma, Y Qu - ACS Catalysis, 2023 - ACS Publications
Adsorption of molecules on active sites of heterogeneous catalysts significantly affects their
catalytic performance, which provides a perspective to understand the catalytic …

Catalytic homogeneous asymmetric hydrogenation: successes and opportunities

CSG Seo, RH Morris - Organometallics, 2018 - ACS Publications
This is an overview of successes in the realm of catalytic homogeneous asymmetric
hydrogenation of substrates primarily of interest in the synthesis of pharmaceuticals in order …

Transition metal catalysis in living cells: progress, challenges, and novel supramolecular solutions

CC James, B de Bruin, JNH Reek - Angewandte Chemie, 2023 - Wiley Online Library
The importance of transition metal catalysis is exemplified by its wide range of applications,
for example in the synthesis of chemicals, natural products, and pharmaceuticals. However …