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Organometallic anti-tumor agents: targeting from biomolecules to dynamic bioprocesses
The great clinical success of cisplatin and its derivatives has convinced people that metal
complexes could play a more significant role in human cancer therapy. However, targeting …
complexes could play a more significant role in human cancer therapy. However, targeting …
Metallodrugs are unique: opportunities and challenges of discovery and development
EJ Anthony, EM Bolitho, HE Bridgewater… - Chemical …, 2020 - pubs.rsc.org
Metals play vital roles in nutrients and medicines and provide chemical functionalities that
are not accessible to purely organic compounds. At least 10 metals are essential for human …
are not accessible to purely organic compounds. At least 10 metals are essential for human …
Bioorthogonal catalytic patch
Bioorthogonal catalysis mediated by transition metals has inspired a new subfield of artificial
chemistry complementary to enzymatic reactions, enabling the selective labelling of …
chemistry complementary to enzymatic reactions, enabling the selective labelling of …
Targeted photoredox catalysis in cancer cells
Hypoxic tumours are a major problem for cancer photodynamic therapy. Here, we show that
photoredox catalysis can provide an oxygen-independent mechanism of action to combat …
photoredox catalysis can provide an oxygen-independent mechanism of action to combat …
Packaging and delivering enzymes by amorphous metal-organic frameworks
X Wu, H Yue, Y Zhang, X Gao, X Li, L Wang… - Nature …, 2019 - nature.com
Enzymatic catalysis in living cells enables the in-situ detection of cellular metabolites in
single cells, which could contribute to early diagnosis of diseases. In this study, enzyme is …
single cells, which could contribute to early diagnosis of diseases. In this study, enzyme is …
An ultrasound-activatable platinum prodrug for sono-sensitized chemotherapy
Despite the great success achieved by photoactivated chemotherapy, eradicating deep
tumors using external sources with high tissue penetration depth remains a challenge. Here …
tumors using external sources with high tissue penetration depth remains a challenge. Here …
Metal complexes for therapeutic applications
Metal complexes have been widely used for applications in the chemical and physical
sciences due to their unique electronic and stereochemical properties. For decades the use …
sciences due to their unique electronic and stereochemical properties. For decades the use …
Adsorption of Molecules on Defective CeO2 for Advanced Catalysis
S Zhang, Z Tian, Y Ma, Y Qu - ACS Catalysis, 2023 - ACS Publications
Adsorption of molecules on active sites of heterogeneous catalysts significantly affects their
catalytic performance, which provides a perspective to understand the catalytic …
catalytic performance, which provides a perspective to understand the catalytic …
Catalytic homogeneous asymmetric hydrogenation: successes and opportunities
CSG Seo, RH Morris - Organometallics, 2018 - ACS Publications
This is an overview of successes in the realm of catalytic homogeneous asymmetric
hydrogenation of substrates primarily of interest in the synthesis of pharmaceuticals in order …
hydrogenation of substrates primarily of interest in the synthesis of pharmaceuticals in order …
Transition metal catalysis in living cells: progress, challenges, and novel supramolecular solutions
CC James, B de Bruin, JNH Reek - Angewandte Chemie, 2023 - Wiley Online Library
The importance of transition metal catalysis is exemplified by its wide range of applications,
for example in the synthesis of chemicals, natural products, and pharmaceuticals. However …
for example in the synthesis of chemicals, natural products, and pharmaceuticals. However …