Glutamate is the major excitatory transmitter in the vertebrate brain. After its release from
presynaptic nerve terminals, it is rapidly taken up by high-affinity sodium-dependent plasma …

Glutamate transporters remove the excitatory neurotransmitter glutamate from the
extracellular space after neurotransmission is complete, by taking glutamate up into neurons …

The plasma membrane transporters for the neurotransmitter glutamate belong to the solute
carrier 1 family. They are secondary active transporters, taking up glutamate into the cell …

Glutamate transporters regulate synaptic concentrations of this neurotransmitter by coupling
its flux to that of sodium and other cations. Available crystal structures of an archeal …

Solute transport across cell membranes is ubiquitous in biology as an essential
physiological process. Secondary active transporters couple the unfavorable process of …

Membrane transporters mediate cellular uptake of nutrients, signaling molecules, and drugs.
Their overall mechanisms are often well understood, but the structural features setting their …

Excitatory amino acid transporters (EAATs) control the glutamate concentration in the
synaptic cleft by glial and neuronal glutamate uptake. Uphill glutamate transport is achieved …

A homeostatic concentration of glutamate in the synaptic cleft ensures a correct signal
transduction along the neuronal network. An unbalance in this concentration can lead to …

Neuronal and glial glutamate transporters limit the action of excitatory amino acids after their
release during synaptic transmission. Recent structural and functional investigations have …

Excitatory amino acid transporters (EAATs) are a class of glutamate transporters that
terminate glutamatergic synaptic transmission in the mammalian CNS. GltPh, an archeal …