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Transitioning single-cell genomics into the clinic
The use of genomics is firmly established in clinical practice, resulting in innovations across
a wide range of disciplines such as genetic screening, rare disease diagnosis and …
a wide range of disciplines such as genetic screening, rare disease diagnosis and …
Unravelling tumour heterogeneity by single-cell profiling of circulating tumour cells
Single-cell technologies have contributed to unravelling tumour heterogeneity, now
considered a hallmark of cancer and one of the main causes of tumour resistance to cancer …
considered a hallmark of cancer and one of the main causes of tumour resistance to cancer …
[HTML][HTML] SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells
The cystine transporter solute carrier family 7 member 11 (SLC7A11; also called xCT)
protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we …
protects cancer cells from oxidative stress and is overexpressed in many cancers. Here we …
[HTML][HTML] Immune checkpoint HLA-E: CD94-NKG2A mediates evasion of circulating tumor cells from NK cell surveillance
X Liu, J Song, H Zhang, X Liu, F Zuo, Y Zhao, Y Zhao… - Cancer cell, 2023 - cell.com
Circulating tumor cells (CTCs), shed by primary malignancies, function as" seeds" for distant
metastasis. However, it is still largely unknown how CTCs escape immune surveillance …
metastasis. However, it is still largely unknown how CTCs escape immune surveillance …
Deregulation of ribosomal protein expression and translation promotes breast cancer metastasis
Circulating tumor cells (CTCs) are shed into the bloodstream from primary tumors, but only a
small subset of these cells generates metastases. We conducted an in vivo genome-wide …
small subset of these cells generates metastases. We conducted an in vivo genome-wide …
[HTML][HTML] The bone microenvironment invigorates metastatic seeds for further dissemination
Metastasis has been considered as the terminal step of tumor progression. However, recent
genomic studies suggest that many metastases are initiated by further spread of other …
genomic studies suggest that many metastases are initiated by further spread of other …
The androgen receptor in breast cancer
P Giovannelli, M Di Donato, G Galasso… - Frontiers in …, 2018 - frontiersin.org
Breast cancer (BC) is a hormone-related tumor. Despite the progress in BC therapy, this
disease still remains the most common cancer amongst women around the world. This is …
disease still remains the most common cancer amongst women around the world. This is …
Liquid biopsies
Liquid biopsy is based on minimally invasive blood tests and has a high potential to
significantly change the therapeutic strategy in cancer patients, providing an extremely …
significantly change the therapeutic strategy in cancer patients, providing an extremely …
Promises and pitfalls of using liquid biopsy for precision medicine
New sensitive assays are currently available for the detection of circulating tumor DNA
(ctDNA) and circulating tumor cells (CTC). However, there remains a need for …
(ctDNA) and circulating tumor cells (CTC). However, there remains a need for …
Androgen receptor in breast cancer—clinical and preclinical research insights
The Androgen Receptor (AR) is emerging as an important factor in the pathogenesis of
breast cancer (BC), which is the most common malignancy among females worldwide. The …
breast cancer (BC), which is the most common malignancy among females worldwide. The …