Protein evolution or engineering studies are traditionally focused on amino acid
substitutions and the way these contribute to fitness. Meanwhile, the insertion and deletion …

Fungi are a diverse group of organisms with a huge variation in reproductive strategy. While
almost all species can reproduce sexually, many reproduce asexually most of the time …

The use of molecular taxonomy for identifying recently diverged species has transformed the
study of speciation in fungi. The pathogenic fungus Paracoccidioides spp has been …

The fidelity of DNA replication together with repair mechanisms ensure that the genetic
material is properly copied from one generation to another. However, on extremely rare …

Mutations are the source of genetic variation and the substrate for evolution. Genome-wide
mutation rates appear to be affected by selection and are probably adaptive. Mutation rates …

Although it is well known that microbial populations can respond adaptively to challenges
from antibiotics, empirical difficulties in distinguishing the roles of de novo mutation and …

Now updated for its second edition, Population Genetics is the classic, accessible
introduction to the concepts of population genetics. Combining traditional conceptual …

The ecology and genetic diversity of the model yeast Saccharomyces cerevisiae before
human domestication remain poorly understood. Taiwan is regarded as part of this yeast's …

By altering the dynamics of DNA replication and repair, alternative ploidy states may
experience different rates and types of new mutations, leading to divergent evolutionary …

Mutations spawn genetic variation which, in turn, fuels evolution. Hence, experimental
investigations into the rate and fitness effects of spontaneous mutations are central to the …