Simple Summary Multiple Myeloma (MM) is a hematologic malignancy caused by aberrant
plasma cell proliferation in the bone marrow (BM) and constitutes the second most common …

Liquid biopsies represent a potential revolution in cancer diagnostics as a noninvasive
method for detecting and monitoring diseases, complementary to or even replacing current …

Platelets have long been known to play important roles beyond hemostasis and thrombosis.
Now recognized as a bona fide mediator of malignant disease, platelets influence various …

The interaction between circulating tumor cells and platelets is a key factor in cancer
metastasis. These interactions, driven by a variety of receptors, support circulating tumor …

Metastasis is the major cause of cancer deaths, and cancer cells evolve to adapt to various
tumor microenvironments, which hinders the treatment of tumor metastasis. Platelets play …

Tumor-educated platelets (TEPs) are potential biomarkers for cancer diagnostics. We
employ TEP-derived RNA panels, determined by swarm intelligence, to detect and monitor …

Blood-based diagnostics tests, using individual or panels of biomarkers, may revolutionize
disease diagnostics and enable minimally invasive therapy monitoring. However, selection …

Beyond traditional roles in homeostasis and coagulation, growing evidence suggests that
platelets also reflect malignant transformation in cancer. Platelets are present in the tumor …

Osteosarcoma is the most common primary malignant bone cancer, with high rates of
pulmonary metastasis. Osteosarcoma patients with pulmonary metastasis have worse …

The reason why a few myeloma cells egress from the bone marrow (BM) into peripheral
blood (PB) remains unknown. Here, we investigated molecular hallmarks of circulating …