Periodontal inflammation and systemic diseases: an overview
Periodontitis is a common inflammatory disease of infectious origins that often evolves into a
chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis …
chronic condition. Aside from its importance as a stomatologic ailment, chronic periodontitis …
GWAS meta-analysis of suicide attempt: identification of 12 genome-wide significant loci and implication of genetic risks for specific health factors
AR Docherty, N Mullins… - American journal of …, 2023 - Am Psychiatric Assoc
Objective: Suicidal behavior is heritable and is a major cause of death worldwide. Two large-
scale genome-wide association studies (GWASs) recently discovered and cross-validated …
scale genome-wide association studies (GWASs) recently discovered and cross-validated …
Therapeutic inhibition of acid-sensing ion channel 1a recovers heart function after ischemia–reperfusion injury
Background: Ischemia–reperfusion injury (IRI) is one of the major risk factors implicated in
morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the …
morbidity and mortality associated with cardiovascular disease. During cardiac ischemia, the …
No bidirectional relationship between depression and periodontitis: A genetic correlation and Mendelian randomization study
Background Observational and in-vivo research suggested a bidirectional relationship
between depression and periodontitis. We estimated the genetic correlation and examined …
between depression and periodontitis. We estimated the genetic correlation and examined …
Genome-wide association study meta-analysis of dizygotic twinning illuminates genetic regulation of female fecundity
STUDY QUESTION Which genetic factors regulate female propensity for giving birth to
spontaneous dizygotic (DZ) twins? SUMMARY ANSWER We identified four new loci …
spontaneous dizygotic (DZ) twins? SUMMARY ANSWER We identified four new loci …
[HTML][HTML] A shared genetic signature for common chronic pain conditions and its impact on biopsychosocial traits
The multiple comorbidities & dimensions of chronic pain present a formidable challenge in
disentangling its aetiology. Here, we performed genome-wide association studies of 8 …
disentangling its aetiology. Here, we performed genome-wide association studies of 8 …
[HTML][HTML] Is periodontitis a risk factor for ischaemic stroke, coronary artery disease and subclinical atherosclerosis? A Mendelian randomization study
Background and aims Observational studies have reported an association between
periodontitis and cardiovascular disease but whether this association is causal is uncertain …
periodontitis and cardiovascular disease but whether this association is causal is uncertain …
Mendelian randomization studies of periodontitis: Understanding benefits and natural limitations in an applied context
Mendelian randomization (MR) is a flexible analytical tool that has been widely applied to
strengthen causal inference in observational epidemiology and is now gaining attention in …
strengthen causal inference in observational epidemiology and is now gaining attention in …
Denture use and risk for cardiometabolic disease: observational and Mendelian randomization analyses
Aims Denture use may potentially increase the risk of cardiometabolic diseases (CMDs), but
the casual relevance and strength of the associations are currently unknown. Methods and …
the casual relevance and strength of the associations are currently unknown. Methods and …
Phenome-wide analysis highlights putative causal relationships between self-reported migraine and other complex traits
Background Migraine is a complex neurological disorder that is considered the most
common disabling brain disorder affecting 14% of people worldwide. The present study …
common disabling brain disorder affecting 14% of people worldwide. The present study …