The transient receptor potential ankyrin (TRPA) channels are Ca 2+-permeable nonselective
cation channels remarkably conserved through the animal kingdom. Mammals have only …

Transient receptor potential vanilloid type 4 (TRPV4) is a calcium-permeable nonselective
cation channel, originally described in 2000 by research teams led by Schultz (Nat Cell Biol …

Nociception is an important physiological process that detects harmful signals and results in
pain perception. In this review, we discuss important experimental evidence involving some …

The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …

The detection and processing of painful stimuli in afferent sensory neurons is critically
dependent on a wide range of different types of voltage-and ligand-gated ion channels …

Control of chronic pain is frequently inadequate and/or associated with intolerable adverse
effects, prompting a frantic search for new therapeutics and new therapeutic targets. Nearly …

Tissue damage evokes an inflammatory response that promotes the removal of harmful
stimuli, tissue repair, and protective behaviors to prevent further damage and encourage …

The transient receptor potential ankyrin 1 (TRPA1), a member of the TRP superfamily of
channels, is primarily localized to a subpopulation of primary sensory neurons of the …

Approximately 20 of the 30 mammalian transient receptor potential (TRP) channel subunits
are expressed by specific neurons and cells within the alimentary canal. They subserve …

The transient receptor potential ankyrin 1 (TRPA1) channel is a nonselective cation channel
belonging to the superfamily of transient receptor potential (TRP) channels. It is …