A major shift is happening within neurophysiology: a population doctrine is drawing level
with the single-neuron doctrine that has long dominated the field. Population-level ideas …

We propose that the entirety of the prefrontal cortex (PFC) can be seen as fundamentally
premotor in nature. By this, we mean that the PFC consists of an action abstraction hierarchy …

Deficits in cognitive control—that is, in the ability to withhold a default pre-potent response in
favour of a more adaptive choice—are common in depression, anxiety, addiction and other …

Deep brain stimulation (DBS) is a promising intervention for treatment-resistant psychiatric
disorders, particularly major depressive disorder (MDD) and obsessive-compulsive disorder …

We propose a new conceptual framework (computational validity) for translation across
species and populations based on the computational similarity between the information …

Humans and other animals evolved to make decisions that extend over time with continuous
and ever-changing options. Nonetheless, the academic study of decision-making is mostly …

When choosing between options, we must associate their values with the actions needed to
select them. We hypothesize that the brain solves this binding problem through neural …

Deep brain stimulation (DBS) is an invasive approach to precise modulation of
psychiatrically relevant circuits. Although it has impressive results in open-label psychiatric …

Brain disorders, in particular mental disorders, might be effectively treated by direct electrical
brain stimulation, but clinical progress requires understanding of therapeutic mechanisms …

The processing of sensory information and the generation of motor commands needed to
produce coordinated actions can interfere with ongoing cognitive tasks. Even simple motor …