Alzheimer's disease (AD) is a progressive neurodegenerative condition characterized by
cognitive dysfunction and synaptic failure. The current therapeutic approaches are mainly …

The cerebellum has long been proposed to play a role in cognitive function, although this
has remained controversial. This idea has received renewed support with the recent …

Spike-timing–dependent plasticity (STDP) is considered as a primary mechanism underlying
formation of new memories during learning. Despite the growing interest in activity …

The cerebellum has been a popular topic for theoretical studies because its structure was
thought to be simple. Since David Marr and James Albus related its function to motor skill …

To survive, animals must adapt synaptic weights based on external stimuli and rewards. And
they must do so using local, biologically plausible, learning rules--a highly nontrivial …

Sensory cortices modulate innate behaviors through corticofugal projections targeting
phylogenetically-old brainstem nuclei. However, the principles behind the functional …

The cerebellum plays a critical role in coordinating and learning complex movements.
Although its importance has been well recognized, the mechanisms of learning remain hotly …

The climbing fiber–Purkinje cell circuit is one of the most powerful and highly conserved in
the central nervous system. Climbing fibers exert a powerful excitatory action that results in a …

Synaptic connections in many brain circuits fluctuate, exhibiting substantial turnover and
remodelling over hours to days. Surprisingly, experiments show that most of this flux in …

The cerebellum integrates sensory stimuli and motor actions to enable smooth coordination
and motor learning. Here we harness the innate behavioral repertoire of the larval zebrafish …