The JAK/STAT signaling pathway: from bench to clinic
X Hu, J Li, M Fu, X Zhao, W Wang - Signal transduction and targeted …, 2021 - nature.com
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular …
Targeting cancer stem cell pathways for cancer therapy
L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …
Targeting fibrosis: Mechanisms and clinical trials
M Zhao, L Wang, M Wang, S Zhou, Y Lu… - Signal transduction and …, 2022 - nature.com
Fibrosis is characterized by the excessive extracellular matrix deposition due to
dysregulated wound and connective tissue repair response. Multiple organs can develop …
dysregulated wound and connective tissue repair response. Multiple organs can develop …
Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer
F Wu, J Yang, J Liu, Y Wang, J Mu, Q Zeng… - … and Targeted Therapy, 2021 - nature.com
To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …
Mechanisms and consequences of Jak–STAT signaling in the immune system
Abstract Kinases of the Jak ('Janus kinase') family and transcription factors (TFs) of the STAT
('signal transducer and activator of transcription') family constitute a rapid membrane-to …
('signal transducer and activator of transcription') family constitute a rapid membrane-to …
JAK–STAT signaling as a target for inflammatory and autoimmune diseases: current and future prospects
The Janus kinase/signal transduction and activator of transcription (JAK–STAT) signaling
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …
pathway is implicated in the pathogenesis of inflammatory and autoimmune diseases …
The JAK-STAT pathway: impact on human disease and therapeutic intervention
The Janus kinase (JAK)–signal transducer of activators of transcription (STAT) pathway is
now recognized as an evolutionarily conserved signaling pathway employed by diverse …
now recognized as an evolutionarily conserved signaling pathway employed by diverse …
Antiviral actions of interferons
CE Samuel - Clinical microbiology reviews, 2001 - Am Soc Microbiol
Tremendous progress has been made in understanding the molecular basis of the antiviral
actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the …
actions of interferons (IFNs), as well as strategies evolved by viruses to antagonize the …
Alternative activation of macrophages: an immunologic functional perspective
FO Martinez, L Helming, S Gordon - Annual review of …, 2009 - annualreviews.org
Macrophages are innate immune cells with well-established roles in the primary response to
pathogens, but also in tissue homeostasis, coordination of the adaptive immune response …
pathogens, but also in tissue homeostasis, coordination of the adaptive immune response …
The emerging safety profile of JAK inhibitors in rheumatic disease
KL Winthrop - Nature Reviews Rheumatology, 2017 - nature.com
Tofacitinib is the first Janus kinase (JAK) inhibitor commercially approved for the treatment of
rheumatoid arthritis. This compound and a number of other JAK inhibitors are currently …
rheumatoid arthritis. This compound and a number of other JAK inhibitors are currently …