Tuberculosis (TB) drug discovery and development has undergone nothing short of a
revolution over the past 20 years. Successful public–private partnerships and sustained …

Tuberculosis (TB) is one of the oldest human diseases and is one of the major causes of
mortality and morbidity across the Globe. Mycobacterium tuberculosis (Mtb), the causal …

Induction of lipid-laden foamy macrophages is a cellular hallmark of tuberculosis (TB)
disease, which involves the transformation of infected phagolysosomes from a site of killing …

Chronic inflammation in many infectious and metabolic diseases, and some cancers, is
accompanied by the presence of foam cells. These cells form when the intracellular lipid …

Caseum, the central necrotic material of tuberculous lesions, is a reservoir of drug-
recalcitrant persisting mycobacteria. Caseum is found in closed nodules and in open …

Tuberculosis (TB) is a leading cause of death worldwide following infection with
Mycobacterium tuberculosis (Mtb), with 1.5 million deaths from this disease reported in …

The remarkable ability of Mycobacterium tuberculosis to survive attacks from the host
immune response and drug treatment is due to the resilience of a few bacilli rather than a …

Acidic pH arrests the growth of Mycobacterium tuberculosis in vitro (pH< 5.8) and is thought
to significantly contribute to the ability of macrophages to control M. tuberculosis replication …

While the existence of a special relationship between Mycobacterium tuberculosis (Mtb) and
host lipids has long been known, it remains a challenging enigma. It was clearly established …

Pulmonary surfactants play a crucial role in managing lung lipid metabolism, and
dysregulation of this process is evident in various lung diseases. Alternations in lipid …