DNA methylation is a crucial epigenetic modification of the genome that is involved in
regulating many cellular processes. These include embryonic development, transcription …

This year is the tenth anniversary of the publication in this journal of a model suggesting the
existence of'tumour progenitor genes'. These genes are epigenetically disrupted at the …

Genomic imprinting affects several dozen mammalian genes and results in the expression of
those genes from only one of the two parental chromosomes. This is brought about by …

CTCF is a highly conserved zinc finger protein implicated in diverse regulatory functions,
including transcriptional activation/repression, insulation, imprinting, and X chromosome …

Mammalian SWI/SNF chromatin remodelling complexes exist in three distinct, final-form
assemblies: canonical BAF (cBAF), PBAF and a newly characterized non-canonical complex …

The emerging awareness of the contribution of epigenetic processes to genome function in
health and disease is underpinned by decades of research in model systems. In particular …

Genome function, replication, integrity, and propagation rely on the dynamic structural
organization of chromosomes during the cell cycle. Genome folding in interphase provides …

Understanding how transcriptional enhancers control over 20,000 protein-coding genes to
maintain cell-type-specific gene expression programs in all human cells is a fundamental …

Insulator elements affect gene expression by preventing the spread of heterochromatin and
restricting transcriptional enhancers from activation of unrelated promoters. In vertebrates …

We hypothesized that DNA methylation distributes into specific patterns in cancer cells,
which reflect critical biological differences. We therefore examined the methylation profiles of …