Principles of DNA methylation and their implications for biology and medicine
DNA methylation represents an annotation system for marking the genetic text, thus
providing instruction as to how and when to read the information and control transcription …
providing instruction as to how and when to read the information and control transcription …
[HTML][HTML] Obesity pandemic: causes, consequences, and solutions—but do we have the will?
DR Meldrum, MA Morris, JC Gambone - Fertility and sterility, 2017 - Elsevier
Obesity has become pandemic owing to an obesogenic environment (inexpensive calorie
dense food, technologies and structure of communities that reduce or replace physical …
dense food, technologies and structure of communities that reduce or replace physical …
Placental origins of chronic disease
Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …
events during their intrauterine phase of development. Biologically this should not be …
Maternal microbiota, early life colonization and breast milk drive immune development in the newborn
C Kalbermatter, N Fernandez Trigo… - Frontiers in …, 2021 - frontiersin.org
The innate immune system is the oldest protection strategy that is conserved across all
organisms. Although having an unspecific action, it is the first and fastest defense …
organisms. Although having an unspecific action, it is the first and fastest defense …
[HTML][HTML] Homeostasis, inflammation, and disease susceptibility
ME Kotas, R Medzhitov - Cell, 2015 - cell.com
While modernization has dramatically increased lifespan, it has also witnessed the
increasing prevalence of diseases such as obesity, hypertension, and type 2 diabetes. Such …
increasing prevalence of diseases such as obesity, hypertension, and type 2 diabetes. Such …
Early developmental conditioning of later health and disease: physiology or pathophysiology?
MA Hanson, PD Gluckman - Physiological reviews, 2014 - journals.physiology.org
Extensive experimental animal studies and epidemiological observations have shown that
environmental influences during early development affect the risk of later pathophysiological …
environmental influences during early development affect the risk of later pathophysiological …
Maternal diabetes during pregnancy and early onset of cardiovascular disease in offspring: population based cohort study with 40 years of follow-up
Objective To evaluate the associations between maternal diabetes diagnosed before or
during pregnancy and early onset cardiovascular disease (CVD) in offspring during their first …
during pregnancy and early onset cardiovascular disease (CVD) in offspring during their first …
Long-term cardiovascular consequences of fetal growth restriction: biology, clinical implications, and opportunities for prevention of adult disease
In the modern world, cardiovascular disease is a leading cause of death for both men and
women. Epidemiologic studies consistently have suggested an association between low …
women. Epidemiologic studies consistently have suggested an association between low …
How nutrition and the maternal microbiota shape the neonatal immune system
AJ Macpherson, MG De Agüero… - Nature Reviews …, 2017 - nature.com
The mucosal surfaces of mammals are densely colonized with microorganisms that are
commonly referred to as the commensal microbiota. It is believed that the fetus in utero is …
commonly referred to as the commensal microbiota. It is believed that the fetus in utero is …
Psychoneuroimmunology of early-life stress: the hidden wounds of childhood trauma?
The brain and the immune system are not fully formed at birth, but rather continue to mature
in response to the postnatal environment. The two-way interaction between the brain and …
in response to the postnatal environment. The two-way interaction between the brain and …