Circadian rhythm disruption in critically ill patients
M Felten, C Dame, G Lachmann, C Spies… - Acta …, 2023 - Wiley Online Library
Patients admitted to the intensive care unit (ICU) are in need of continuous organ
replacement strategies and specialized care, for example because of neurological …
replacement strategies and specialized care, for example because of neurological …
[HTML][HTML] Intermittent feeding and circadian rhythm in critical illness
Aligning timing of nutritional intake, physical activity, and/or medication with circadian
rhythms are potential strategies to reset peripheral circadian rhythms and may enhance ICU …
rhythms are potential strategies to reset peripheral circadian rhythms and may enhance ICU …
Causes, consequences, and treatments of sleep and circadian disruption in the ICU: an official American Thoracic Society Research Statement
Background: Sleep and circadian disruption (SCD) is common and severe in the ICU. On the
basis of rigorous evidence in non-ICU populations and emerging evidence in ICU …
basis of rigorous evidence in non-ICU populations and emerging evidence in ICU …
Platform-independent estimation of human physiological time from single blood samples
Abundant epidemiological evidence links circadian rhythms to human health, from heart
disease to neurodegeneration. Accurate determination of an individual's circadian phase is …
disease to neurodegeneration. Accurate determination of an individual's circadian phase is …
Ventilator-induced lung injury is modulated by the circadian clock
M Felten, S Ferencik, LG Teixeira Alves… - American Journal of …, 2023 - atsjournals.org
Rationale: Mechanical ventilation (MV) is life-saving but may evoke ventilator-induced lung
injury (VILI). Objectives: To explore how the circadian clock modulates severity of murine …
injury (VILI). Objectives: To explore how the circadian clock modulates severity of murine …
Circadian patterns of heart rate, respiratory rate and skin temperature in hospitalized COVID-19 patients
HMR van Goor, K van Loon, MJM Breteler… - PLoS …, 2022 - journals.plos.org
Rationale Vital signs follow circadian patterns in both healthy volunteers and critically ill
patients, which seem to be influenced by disease severity in the latter. In this study we …
patients, which seem to be influenced by disease severity in the latter. In this study we …
ClinCirc identifies alterations of the circadian peripheral oscillator in critical care patients
PS Cunningham, GB Kitchen… - The Journal of …, 2023 - Am Soc Clin Investig
Background Assessing circadian rhythmicity from infrequently sampled data is challenging;
however, these types of data are often encountered when measuring circadian transcripts in …
however, these types of data are often encountered when measuring circadian transcripts in …
Disruption of the circadian rhythm of melatonin: A biomarker of critical illness severity
MA Melone, TC Becker, LH Wendt, P Ten Eyck… - Sleep medicine, 2023 - Elsevier
Circadian dysrhythmias occur commonly in critically ill patients reflecting variable effects of
underlying illness, ICU environment, and treatments. We retrospectively analyzed the …
underlying illness, ICU environment, and treatments. We retrospectively analyzed the …
A timely call to arms: COVID-19, the circadian clock, and critical care
We currently find ourselves in the midst of a global coronavirus disease 2019 (COVID-19)
pandemic, caused by the highly infectious novel coronavirus, severe acute respiratory …
pandemic, caused by the highly infectious novel coronavirus, severe acute respiratory …
[HTML][HTML] Enhancing circadian rhythms—the circadian MEGA bundle as novel approach to treat critical illness
M Prin, J Bertazzo, LA Walker, B Scott… - Annals of translational …, 2023 - ncbi.nlm.nih.gov
Circadian rhythms are essential to physiological homeostasis, but often disrupted in the
intensive care unit (ICU) due to the absence of natural zeitgebers and exposure to …
intensive care unit (ICU) due to the absence of natural zeitgebers and exposure to …