Inflammatory bowel disease (IBD) affects 6.8 million people globally. A variety of factors
have been implicated in IBD pathogenesis, including host genetics, immune dysregulation …

Aberrant glycosylation plays a fundamental role in key pathological steps of tumour
development and progression. Glycans have roles in cancer cell signalling, tumour cell …

Neoplastic transformation results in a wide variety of cellular alterations that impact the
growth, survival, and general behavior of affected tissue. Although genetic alterations …

Simple and complex carbohydrates (glycans) have long been known to play major
metabolic, structural and physical roles in biological systems. Targeted microbial binding to …

During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …

Glycans linked to proteins and lipids play key roles in biology; thus, accurate replication of
cellular glycans is crucial for maintaining function following cell division. The fact that …

Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is
important not only for antigen presentation, but also for the induction of appropriate adaptive …

Mucin-type O-glycans are a class of glycans initiated with N-acetylgalactosamine (GalNAc) α-
linked primarily to Ser/Thr residues within glycoproteins and often extended or branched by …

Glycosylation is one of the major posttranslational modifications of proteins. N‐glycosylation
(Asn‐linked) and O‐glycosylation (Ser/Thr‐linked) are the two main forms. Abnormal O …

Prostate cancer is the most common cancer in men and it is estimated that over 350,000
men worldwide die of prostate cancer every year. There remains an unmet clinical need to …