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[PDF][PDF] Tryptophan-kynurenine pathway is dysregulated in inflammation, and immune activation
The kynurenine (Kyn) pathway is the major route for tryptophan (Trp) metabolism, and it
contributes to several fundamental biological processes. Trp is constitutively oxidized by …
contributes to several fundamental biological processes. Trp is constitutively oxidized by …
Understanding the role of the kynurenine pathway in human breast cancer immunobiology
Breast cancer (BrCa) is the leading cause of cancer related death in women. While current
diagnostic modalities provide opportunities for early medical intervention, significant …
diagnostic modalities provide opportunities for early medical intervention, significant …
Diphenyl diselenide administration enhances cortical mitochondrial number and activity by increasing hemeoxygenase type 1 content in a methylmercury-induced …
Interest in biochemistry of organoselenium compound has increased in the last decades,
mainly due to their chemical and biological activities. Here, we investigated the protective …
mainly due to their chemical and biological activities. Here, we investigated the protective …
Kynurenines with neuroactive and redox properties: relevance to aging and brain diseases
J Reyes Ocampo, R Lugo Huitrón… - Oxidative Medicine …, 2014 - Wiley Online Library
The kynurenine pathway (KP) is the main route of tryptophan degradation whose final
product is NAD+. The metabolism of tryptophan can be altered in ageing and with …
product is NAD+. The metabolism of tryptophan can be altered in ageing and with …
Neurological manifestations of organic acidurias
Organic acidurias (OADs) are inherited neurometabolic diseases largely caused by
deficiencies in enzymes involved in amino acid degradation, which result in accumulation of …
deficiencies in enzymes involved in amino acid degradation, which result in accumulation of …
Neuroprotective Effect of Physical Exercise in a Mouse Model of Alzheimer's Disease Induced by β-Amyloid1–40 Peptide
LC Souza, CB Filho, ATR Goes, LD Fabbro… - Neurotoxicity …, 2013 - Springer
This study was designed to investigate the potential neuroprotective effect of exercise in a
mouse model of Alzheimer's disease (AD) induced by intracerebroventricular (icv) injection …
mouse model of Alzheimer's disease (AD) induced by intracerebroventricular (icv) injection …
Profiling of oxidative stress in patients with inborn errors of metabolism
Free radical formation resulting in oxidative stress is a hallmark of mitochondrial dysfunction.
Indeed, oxidative stress has been demonstrated to be an underlying pathophysiologic …
Indeed, oxidative stress has been demonstrated to be an underlying pathophysiologic …
In Vivo Manganese Exposure Modulates Erk, Akt and Darpp-32 in the Striatum of Develo** Rats, and Impairs Their Motor Function
Manganese (Mn) is an essential metal for development and metabolism. However,
exposures to high Mn levels may be toxic, especially to the central nervous system (CNS) …
exposures to high Mn levels may be toxic, especially to the central nervous system (CNS) …
Disruption of mitochondrial homeostasis in organic acidurias: insights from human and animal studies
Organic acidurias or organic acidemias constitute a group of inherited disorders caused by
deficient activity of specific enzymes of amino acids, carbohydrates or lipids catabolism …
deficient activity of specific enzymes of amino acids, carbohydrates or lipids catabolism …
Effects of inorganic selenium administration in methylmercury-induced neurotoxicity in mouse cerebral cortex
Selenium can counteract methylmercury (MeHg) neurotoxicity. However, data about the
neuroprotective effects of sodium selenite (Na2SeO3) on the activity of mitochondrial …
neuroprotective effects of sodium selenite (Na2SeO3) on the activity of mitochondrial …