Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …

The hypothalamus is an evolutionarily conserved brain structure that regulates an
organism's basic functions, such as homeostasis and reproduction. Several hypothalamic …

Ghrelin is a multifaceted regulator of metabolism. Ghrelin regulates energy balance in the
short term via induction of appetite and in the long term via increased body weight and …

Understanding the complex action mechanism of appetite regulation peptides can
significantly impact therapeutic options in the treatment of obesity and other metabolic …

The peripheral peptide hormone ghrelin is a powerful stimulator of food intake, which leads
to body weight gain and adiposity in both rodents and humans. The hormone, thus …

Ghrelin is a 28 amino acid peptide mainly derived from the oxyntic gland of the stomach.
Both acylated (AG) and unacylated (UAG) forms of ghrelin are found in the circulation …

Regulation of energy homeostasis is fundamental for life. In animal species and humans, the
Central Nervous System (CNS) plays a critical role in such regulation by integrating …

Objective Exercise training has several well-established health benefits, including many
related to body weight, appetite control, and blood glucose homeostasis. However, the …

Objective Ghrelin is a stomach-derived hormone that affects food intake and regulates blood
glucose. The best-characterized actions of ghrelin are mediated by its binding to and …

Activation of central PPARγ promotes food intake and body weight gain; however, the
identity of the neurons that express PPARγ and mediate the effect of this nuclear receptor on …